Soliman R, Mokhtar H, El Ashry E S
Pharmazie. 1978 Apr;33(4):184-5. doi: 10.1002/chin.197843242.
Condensation of ethyl 2,4-dioxo-6-phenyl hex-5-enoate (1) with 4-substituted sulphamyl phenylhydrazines (2) led to 1-aryl-3-ethoxycarbonyl-5-styrylpyrazoles (3) which on hydrolysis gave 1-aryl-5-styrylpyrazole-3-carboxylic acids (4) and upon permanganate oxidation gave 1-aryl-3-ethoxycarbonylpyrazole-5-carboxylic acids (5). Similar condensation of hydralazine (6) with (1) gave the corresponding pyrazole (7) which on hydrolysis gave the acid 8.
2,4-二氧代-6-苯基己-5-烯酸乙酯（1）与4-取代氨磺酰基苯肼（2）缩合生成1-芳基-3-乙氧羰基-5-苯乙烯基吡唑（3），（3）水解得到1-芳基-5-苯乙烯基吡唑-3-羧酸（4），经高锰酸钾氧化得到1-芳基-3-乙氧羰基吡唑-5-羧酸（5）。肼苯哒嗪（6）与（1）进行类似的缩合反应得到相应的吡唑（7），（7）水解得到酸8。
