芫荽果实精油的抗真菌活性、毒性及化学成分。
Antifungal activity, toxicity and chemical composition of the essential oil of Coriandrum sativum L. fruits.
机构信息
Postgraduate Program in Veterinary Sciences, State University of Ceará, 60740-000 Fortaleza, CE, Brazil.
出版信息
Molecules. 2012 Jul 11;17(7):8439-48. doi: 10.3390/molecules17078439.
Abstract
The aims of this study were to test the antifungal activity, toxicity and chemical composition of essential oil from C. sativum L. fruits. The essential oil, obtained by hydro-distillation, was analyzed by gas chromatography/mass spectroscopy. Linalool was the main constituent (58.22%). The oil was considered bioactive, showing an LC₅₀ value of 23 μg/mL in the Artemia salina lethality test. The antifungal activity was evaluated against Microsporum canis and Candida spp. by the agar-well diffusion method and the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were established by the broth microdilution method. The essential oil induced growth inhibition zones of 28 ± 5.42 and 9.25 ± 0.5 for M. canis and Candida spp. respectively. The MICs and MFCs for M. canis strains ranged from 78 to 620 and 150 to 1,250 μg/mL, and the MICs and MFCs for Candida spp strains ranged from 310 to 620 and 620 to 1,250 μg/mL, respectively. C. sativum essential oil is active in vitro against M. canis and Candida spp. demonstrating good antifungal activity.
摘要
本研究旨在测试 C. sativum L. 果实精油的抗真菌活性、毒性和化学成分。通过水蒸馏法获得的精油通过气相色谱/质谱法进行分析。芳樟醇是主要成分（58.22%）。该油被认为具有生物活性，在卤虫致死试验中 LC₅₀ 值为 23 μg/mL。通过琼脂扩散法评估了精油对犬小孢子菌和念珠菌属的抗真菌活性，并通过肉汤微量稀释法确定了最小抑菌浓度（MIC）和最小杀菌浓度（MFC）。精油对犬小孢子菌和念珠菌属分别诱导了 28 ± 5.42 和 9.25 ± 0.5 的抑菌圈。犬小孢子菌菌株的 MIC 和 MFC 范围分别为 78 至 620 和 150 至 1,250 μg/mL，念珠菌属菌株的 MIC 和 MFC 范围分别为 310 至 620 和 620 至 1,250 μg/mL。C. sativum 精油对犬小孢子菌和念珠菌属具有体外活性，表现出良好的抗真菌活性。
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