ESHRE Central Office, Meerstraat 60, B-1852 Grimbergen, Belgium.
Hum Reprod. 2012 Sep;27(9):2571-84. doi: 10.1093/humrep/des255. Epub 2012 Jul 10.
This 12th European IVF-monitoring (EIM) report presents the results of treatments involving assisted reproductive technology (ART) initiated in Europe during 2008.
From 36 countries (3 more compared with 2007), 1051 clinics reported 532 260 treatment cycles including: IVF (124 539), ICSI (280 552), frozen embryo replacements (FER, 97 120), egg donation (ED, 13 609), in vitro maturation (IVM, 562), preimplantation genetic diagnosis/screening (PGD/PGS, 2875) and frozen oocyte replacements (FOR, 4080). Overall, this represents a 7.9% increase in the activity since 2007, which is mainly related to an increase in cycles from almost all registers and only partially to the new countries entering EIM (Estonia, Kazakhstan, Moldova and Romania, 5480 cycles in total). European data on intrauterine insemination using husband/partner's (IUI-H) and donor (IUI-D) semen were reported from 27 and 21 countries, respectively. A total of 144 509 IUI-H (+1.5%) and 24 960 IUI-D (-4.3%) cycles were included.
In 19 countries where all clinics reported to the ART register, a total of 350 143 ART cycles were performed in a population of 369.8 million, corresponding to 947 cycles per million inhabitants. For IVF, the clinical pregnancy rates per aspiration and per transfer were 28.5 and 32.5%, respectively, and for ICSI the corresponding rates were 28.7 and 31.9%. In FER cycles, the pregnancy rate per thawing was 19.3%. The delivery rate after IUI was 9.1% for IUI-H and 13.8% for IUI-D. In IVF and ICSI cycles, one, two, three and four or more embryos were transferred in 22.4, 53.2, 22.3 and 2.1%, respectively. The proportions of singleton, twin and triplet deliveries after IVF and ICSI (combined) were 78.3, 20.7 and 1.0%, respectively, resulting in a total multiple delivery rate of 21.7%, compared with 22.3% in 2007, 20.8% in 2006 and 21.8% in 2005. In FER cycles, the multiple delivery rate was 13.7% (13.4% twins and 0.3% triplets). In women undergoing IUI, twin and triplet deliveries occurred in 10.6% and 0.7% with IUI-H and in 9.4 and 0.3% with IUI-D, respectively.
In comparison with previous years, there was an increase in the reported number of ART cycles in Europe. For the first time in 5 years, the pregnancy rates failed to show a year-on-year increase. Compared with 2007, the number of transfers of multiple embryos (3+) and a multiple delivery rate showed a marginal decline.
本报告是第 12 份欧洲体外受精监测（EIM）报告，展示了 2008 年在欧洲启动的辅助生殖技术（ART）治疗的结果。
来自 36 个国家（比 2007 年增加 3 个）的 1051 家诊所报告了 532260 个治疗周期，包括 IVF（124539 个）、ICSI（280552 个）、冷冻胚胎替换（FER，97120 个）、卵子捐赠（ED，13609 个）、体外成熟（IVM，562 个）、胚胎植入前遗传学诊断/筛查（PGD/PGS，2875 个）和冷冻卵母细胞替换（FOR，4080 个）。总的来说，这比 2007 年增长了 7.9%，这主要是由于来自几乎所有登记处的周期增加，部分原因是新进入 EIM 的国家（爱沙尼亚、哈萨克斯坦、摩尔多瓦和罗马尼亚，总共 5480 个周期）。分别有 27 个和 21 个国家报告了使用丈夫/伴侣精液（IUI-H）和供体精液（IUI-D）进行宫腔内人工授精的欧洲数据。共包括 144509 个 IUI-H（增长 1.5%）和 24960 个 IUI-D（下降 4.3%）周期。
在 19 个所有诊所都向 ART 登记处报告的国家中，在 36980 万人口中，共进行了 350143 个 ART 周期，相当于每百万居民 947 个周期。对于 IVF，每个抽吸和每个转移的临床妊娠率分别为 28.5%和 32.5%，对于 ICSI，相应的妊娠率分别为 28.7%和 31.9%。在 FER 周期中，解冻后的妊娠率为 19.3%。IUI 后的分娩率为 IUI-H 9.1%，IUI-D 13.8%。在 IVF 和 ICSI 周期中，分别有 22.4%、53.2%、22.3%和 2.1%转移一个、两个、三个和四个或更多胚胎。IVF 和 ICSI（合并）后的单胎、双胎和三胎分娩比例分别为 78.3%、20.7%和 1.0%，总多胎分娩率为 21.7%，而 2007 年为 22.3%，2006 年为 20.8%，2005 年为 21.8%。在 FER 周期中，多胎分娩率为 13.7%（双胞胎 13.4%，三胞胎 0.3%）。在接受 IUI 的女性中，IUI-H 的双胞胎和三胞胎分娩率分别为 10.6%和 0.7%，IUI-D 为 9.4%和 0.3%。
与前几年相比，欧洲报告的 ART 周期数量有所增加。妊娠率与去年相比首次出现持平。与 2007 年相比，多胚胎（3+）转移数量和多胎分娩率略有下降。
