Kawase T, Kobayashi T, Takasaka T, Shinkawa H
Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
Eur Arch Otorhinolaryngol. 1990;247(6):364-7. doi: 10.1007/BF00179008.
The effect of perilymphatic pressure on the cochlear microphonics (CM) threshold was examined in guinea pigs with experimentally induced hydrops. When a pressure of 300 mm H2O was applied to the scala tympani of the basal turn, the 500 Hz CM threshold shifts in ears during the 1st week following obliteration of the endolymphatic sac and duct were significantly smaller when compared with shifts in normal ears. Larger threshold shifts were then regained at 4-12 weeks after surgery. When acetazolamide was administered to hydropic animals, the effect of the increase of perilymphatic pressure on the CM threshold was also investigated. During the 1st postoperative week (4-7 days after surgery), CM threshold shifts were larger when compared to changes in hydropic animals without medication. The CM depression as the result of pressure is probably due to a mechanical effect on the intracochlear partition.
在实验性诱发积水的豚鼠中，研究了外淋巴压力对耳蜗微音器（CM）阈值的影响。当向蜗底鼓阶施加300毫米水柱的压力时，在内淋巴囊和导管闭塞后的第1周内，与正常耳相比，积水耳中500赫兹CM阈值的变化明显更小。然后在术后4至12周恢复较大的阈值变化。当给积水动物服用乙酰唑胺时，还研究了外淋巴压力升高对CM阈值的影响。在术后第1周（手术后4至7天），与未用药的积水动物相比，CM阈值变化更大。压力导致的CM降低可能是由于对耳蜗内隔的机械作用。
