Shinkawa H, Kimura R S
Acta Otolaryngol. 1986 Jan-Feb;101(1-2):43-52. doi: 10.3109/00016488609108606.
The effect of diuretics on endolymphatic hydrops, which was produced by obliteration of the endolymphatic duct and sac in guinea pigs, was determined by statistical analysis of volumetric changes in the scala media. When acetazolamide was administered orally at 159 to 434 mg/kg per day for a period of 30 days, endolymphatic hydrops did not reach the extent of distension shown in animal ears without drug treatment. No difference was seen in animals with one month of drug treatment followed by three additional months without treatment. This result suggests that acetazolamide has the effect of reducing endolymphatic hydrops only during the period of drug administration. On the other hand, there appeared to be no effect, statistically, on hydrops in animals which were treated with chlorthalidone 72 to 182 mg/kg every other day for one month with survival times varying from one to four months. The effect of this drug favorably reported for the treatment of Meniere's disease symptoms is not demonstrated on endolymphatic hydrops, but rather is likely to involve other mechanisms. There was no essential difference in the extent of cochlear sensory and neural atrophy in the inner ears of animals with or without these drug treatments.
通过对豚鼠中阶体积变化进行统计分析，确定了利尿剂对因内淋巴管和内淋巴囊闭塞所产生的内淋巴积水的影响。当以每天159至434毫克/千克的剂量口服乙酰唑胺，持续30天时，内淋巴积水未达到未接受药物治疗动物耳部所呈现的扩张程度。在接受一个月药物治疗后再额外三个月不治疗的动物中未观察到差异。这一结果表明，乙酰唑胺仅在给药期间具有减轻内淋巴积水的作用。另一方面，对于每隔一天用72至182毫克/千克氯噻酮治疗一个月、存活时间从一至四个月不等的动物，统计学上似乎对积水没有影响。这种药物在治疗梅尼埃病症状方面所报道的有益效果在对内淋巴积水方面未得到证实，而更可能涉及其他机制。接受或未接受这些药物治疗的动物内耳中，耳蜗感觉和神经萎缩程度没有本质差异。
