Ba Fang, Giuliani Fabrizio, Camicioli Richard, Saqqur Maher
Division of Neurology, University of Alberta, Edmonton, Canada.
BMJ Case Rep. 2012 Jul 11;2012:bcr0920114841. doi: 10.1136/bcr.09.2011.4841.
Reversible cerebral vasoconstriction syndrome (RCVS) is typically presented with severe headaches where, vascular imaging demonstrates multiple intracranial arterial narrowing. Variable triggers are related to RCVS, such as serotonin agents and bromocriptine. Thus, a detailed medication history is important. Subarachnoid haemorrhage (SAH) is not uncommon in RCVS. Repeat vascular imaging at 2-3 months with complete reversal of the narrowed vessels confirms the diagnosis of RCVS. The authors present a case where use of triptan along with multiple psychotropic medications, was associated with RVCS. Neuroimaging demonstrated focal SAH and diffuse beaded appearance involving the intracranial vasculature. The patient improved clinically with oral nimodipine treatment. Repeat angiography and a follow-up transcranial Doppler showed complete resolution of vasoconstriction. In the setting of acute severe headache, with any 'red flags', it is important to evaluate the medication use and other precipitating risks for RVCS. Vascular imaging is the key for diagnosis.
可逆性脑血管收缩综合征(RCVS)通常表现为严重头痛,血管成像显示多条颅内动脉狭窄。RCVS有多种诱发因素,如血清素类药物和溴隐亭。因此,详细的用药史很重要。蛛网膜下腔出血(SAH)在RCVS中并不少见。在2 - 3个月时重复血管成像,狭窄血管完全逆转可确诊RCVS。作者报告了一例使用曲坦类药物及多种精神药物与RCVS相关的病例。神经影像学显示局灶性SAH和颅内血管弥漫性串珠样表现。患者口服尼莫地平治疗后临床症状改善。重复血管造影和随访经颅多普勒显示血管收缩完全缓解。在急性严重头痛伴有任何“警示信号”的情况下,评估药物使用情况和其他RCVS的诱发风险很重要。血管成像是诊断的关键。