Institute of Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany.
J Virol. 2012 Oct;86(19):10866-9. doi: 10.1128/JVI.01472-12. Epub 2012 Jul 11.
The transfer of T cell receptor (TCR) genes by viral vectors represents a promising technique to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells specific for infectious pathogens have been described, but their protective function in vivo has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14 TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective activities in both viral and bacterial infection models in mice.
通过病毒载体转移 T 细胞受体（TCR）基因是一种很有前途的技术，可以为过继免疫疗法生成抗原特异性 T 细胞。已经描述了针对传染性病原体的 TCR 转导 T 细胞，但它们在体内的保护功能尚未得到检验。在这里，我们证明了针对淋巴细胞性脉络丛脑膜炎病毒 gp33 表位的 P14 TCR 转导的 CD8 T 细胞在小鼠的病毒和细菌感染模型中具有保护活性。
