病毒特异性 T 细胞受体转导的 CD8 T 细胞在体内的保护能力。
Protective capacity of virus-specific T cell receptor-transduced CD8 T cells in vivo.
机构信息
Institute of Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany.
出版信息
J Virol. 2012 Oct;86(19):10866-9. doi: 10.1128/JVI.01472-12. Epub 2012 Jul 11.
Abstract
The transfer of T cell receptor (TCR) genes by viral vectors represents a promising technique to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells specific for infectious pathogens have been described, but their protective function in vivo has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14 TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective activities in both viral and bacterial infection models in mice.
摘要
通过病毒载体转移 T 细胞受体（TCR）基因是一种很有前途的技术，可以为过继免疫疗法生成抗原特异性 T 细胞。已经描述了针对传染性病原体的 TCR 转导 T 细胞，但它们在体内的保护功能尚未得到检验。在这里，我们证明了针对淋巴细胞性脉络丛脑膜炎病毒 gp33 表位的 P14 TCR 转导的 CD8 T 细胞在小鼠的病毒和细菌感染模型中具有保护活性。
相似文献
1
Protective capacity of virus-specific T cell receptor-transduced CD8 T cells in vivo.病毒特异性 T 细胞受体转导的 CD8 T 细胞在体内的保护能力。
J Virol. 2012 Oct;86(19):10866-9. doi: 10.1128/JVI.01472-12. Epub 2012 Jul 11.
2
2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes.针对 LCMV GP33 表位的 TCR 和 CD8 共受体的 2D 动力学分析。
Front Immunol. 2018 Oct 15;9:2348. doi: 10.3389/fimmu.2018.02348. eCollection 2018.
3
Kinetics of the response of naive and memory CD8 T cells to antigen: similarities and differences.初始和记忆性CD8 T细胞对抗原反应的动力学：异同点
Eur J Immunol. 1999 Jan;29(1):284-90. doi: 10.1002/(SICI)1521-4141(199901)29:01<284::AID-IMMU284>3.0.CO;2-C.
4
Conversion of tyrosine to the inflammation-associated analog 3'-nitrotyrosine at either TCR- or MHC-contact positions can profoundly affect recognition of the MHC class I-restricted epitope of lymphocytic choriomeningitis virus glycoprotein 33 by CD8 T cells.在TCR或MHC接触位点将酪氨酸转化为与炎症相关的类似物3'-硝基酪氨酸，可深刻影响CD8 T细胞对淋巴细胞性脉络丛脑膜炎病毒糖蛋白33的MHC I类限制性表位的识别。
J Immunol. 2008 May 1;180(9):5956-62. doi: 10.4049/jimmunol.180.9.5956.
5
High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine Model.在小鼠模型中，骨髓移植后抗宿主反应性CD8 + T细胞的高频率会忽略非造血抗原。
Cell Physiol Biochem. 2016;38(4):1343-53. doi: 10.1159/000443078. Epub 2016 Mar 24.
6
Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection.表位逃逸对慢性感染期间PD-1表达和CD8 T细胞耗竭的影响。
J Virol. 2009 May;83(9):4386-94. doi: 10.1128/JVI.02524-08. Epub 2009 Feb 11.
7
8
In vivo modulation of T cell responses and protective immunity by TCR antagonism during infection.感染期间通过TCR拮抗作用对T细胞反应和保护性免疫进行体内调节。
J Immunol. 2005 Jun 15;174(12):7970-6. doi: 10.4049/jimmunol.174.12.7970.
9
Differential effect of Listeria monocytogenes infection on cytokine production and cytotoxicity of CD8 T cells.单核细胞增生李斯特菌感染对CD8 T细胞细胞因子产生和细胞毒性的差异影响。
Microbiol Immunol. 2007;51(9):893-901. doi: 10.1111/j.1348-0421.2007.tb03972.x.
10
IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections.在病毒感染早期阶段，无论有无同源抗原存在时，干扰素诱导的CD8 T细胞损耗。
J Immunol. 2006 Apr 1;176(7):4284-95. doi: 10.4049/jimmunol.176.7.4284.
引用本文的文献
1
Updates on Chronic HBV: Current Challenges and Future Goals.慢性乙型肝炎的最新进展：当前挑战与未来目标
Curr Treat Options Gastroenterol. 2019 Jun;17(2):271-291. doi: 10.1007/s11938-019-00236-3.
2
PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma.PD1-CD28 融合蛋白使 CD4+ T 细胞在胰腺癌和非霍奇金淋巴瘤模型中的过继性 T 细胞治疗中获得辅助作用。
Front Immunol. 2018 Aug 30;9:1955. doi: 10.3389/fimmu.2018.01955. eCollection 2018.
3
Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection.短暂表达病毒特异性T细胞受体的淋巴细胞可降低乙型肝炎病毒感染。
J Clin Invest. 2017 Aug 1;127(8):3177-3188. doi: 10.1172/JCI93024. Epub 2017 Jul 24.
本文引用的文献
1
Transduction of SIV-specific TCR genes into rhesus macaque CD8+ T cells conveys the ability to suppress SIV replication.将 SIV 特异性 TCR 基因转导到恒河猴 CD8+ T 细胞中可赋予其抑制 SIV 复制的能力。
PLoS One. 2011;6(8):e23703. doi: 10.1371/journal.pone.0023703. Epub 2011 Aug 23.
2
Engineering T cells specific for a dominant severe acute respiratory syndrome coronavirus CD8 T cell epitope.工程化针对主要严重急性呼吸综合征冠状病毒 CD8 T 细胞表位的 T 细胞。
J Virol. 2011 Oct;85(20):10464-71. doi: 10.1128/JVI.05039-11. Epub 2011 Aug 3.
3
T-cell receptor gene therapy: critical parameters for clinical success.T 细胞受体基因治疗：临床成功的关键参数。
J Invest Dermatol. 2011 Sep;131(9):1806-16. doi: 10.1038/jid.2011.160. Epub 2011 Jun 16.
4
Development of genetically engineered CD4+ and CD8+ T cells expressing TCRs specific for a M. tuberculosis 38-kDa antigen.表达针对结核分枝杆菌 38 kDa 抗原的 TCR 的基因工程 CD4+和 CD8+ T 细胞的开发。
J Mol Med (Berl). 2011 Sep;89(9):903-13. doi: 10.1007/s00109-011-0760-4. Epub 2011 May 10.
5
Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines.工程病毒特异性 T 细胞，以靶向 HBV 感染的肝细胞和肝癌细胞系。
J Hepatol. 2011 Jul;55(1):103-10. doi: 10.1016/j.jhep.2010.10.025. Epub 2010 Nov 23.
6
Adoptive cell therapy: genetic modification to redirect effector cell specificity.过继细胞疗法：基因修饰以重新定向效应细胞特异性。
Cancer J. 2010 Jul-Aug;16(4):336-41. doi: 10.1097/PPO.0b013e3181eb3879.
7
Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity.新型 T 细胞受体转导的人 T 细胞赋予抗 HCV 反应性。
PLoS Pathog. 2010 Jul 29;6(7):e1001018. doi: 10.1371/journal.ppat.1001018.
8
Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy.T 细胞受体基因治疗的小鼠模型中的致命移植物抗宿主病。
Nat Med. 2010 May;16(5):565-70, 1p following 570. doi: 10.1038/nm.2128. Epub 2010 Apr 18.
9
CMV-specific TCR-transgenic T cells for immunotherapy.用于免疫治疗的巨细胞病毒特异性T细胞受体转基因T细胞。
J Immunol. 2009 Nov 15;183(10):6819-30. doi: 10.4049/jimmunol.0902233. Epub 2009 Oct 28.
10
TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008.用于TCR基因治疗的TCR转基因及转基因盒：2008年的现状
Cancer Immunol Immunother. 2009 May;58(5):809-22. doi: 10.1007/s00262-008-0649-4. Epub 2009 Feb 3.
Zotero 插件