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赫伯特·H·贾斯珀与癫痫的基本机制

Herbert H. Jasper and the Basic Mechanisms of the Epilepsies

作者信息

Avoli Massimo

机构信息

Montreal Neurological Institute and Departments of Neurology & Neurosurgery and of Physiology, McGill University, Montréal, H3A 2B4 Québec, Canada;

PMID:22787666
Abstract

Herbert H. Jasper devoted his life to neuroscience and, in particular, to the pathophysiogenesis of epilepsy. He pioneered the EEG as a tool for studying brain activity in relation to states of consciousness, learning, and epileptic discharge. He also used microelectrodes to record the activity of single neurons, and combined electrophysiology with the analysis of the underlying neurochemical mechanisms. For over thirty years Jasper was a driving force in the scientific programs at the Montreal Neurological Institute of McGill University, and for another two decades he contributed vigorously as a leader in neuroscience research at the Université de Montréal. In addition to his research accomplishments, Jasper trained many neuroscientists and was the founding editor of the EEG Journal and a founding member and first President of the American EEG Society. Jasper took part in establishing the International Brain Research Organization (IBRO) to promote collaboration and interchange of scientific information on brain research throughout the world. In the 1960s he was appointed the first Executive Secretary of IBRO. During this period Jasper, along with AA Ward, A Pope and the Public Health Service Advisory Committee on the Epilepsies of the National Institutes of Health, organized the first conference on Basic Mechanisms of the Epilepsies (BME). In 1969 the first BME book was published. Since then, basic and clinical research scientists in epilepsy meet approximately each decade to appraise their accomplishments and to establish future directions.

摘要

赫伯特·H·贾斯珀一生致力于神经科学,尤其专注于癫痫的病理生理发生机制。他开创了将脑电图作为研究大脑活动与意识状态、学习及癫痫放电关系的工具。他还使用微电极记录单个神经元的活动,并将电生理学与对潜在神经化学机制的分析相结合。三十多年来,贾斯珀一直是麦吉尔大学蒙特利尔神经病学研究所科研项目的推动力量,在随后的二十年里,他作为蒙特利尔大学神经科学研究的领导者继续积极贡献。除了研究成果外,贾斯珀还培养了许多神经科学家,他是《脑电图杂志》的创刊编辑,也是美国脑电图协会的创始成员及首任会长。贾斯珀参与创建了国际脑研究组织(IBRO),以促进全球范围内脑研究科学信息的合作与交流。20世纪60年代,他被任命为IBRO的首任执行秘书。在此期间,贾斯珀与AA·沃德、A·波普以及美国国立卫生研究院癫痫公共卫生服务咨询委员会共同组织了首届癫痫基本机制会议(BME)。1969年,第一本关于BME的书籍出版。从那时起,癫痫领域的基础和临床研究科学家大约每十年相聚一次,评估他们的成就并确定未来的方向。

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