Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A. Montreal Neurological Institute, Montreal, Quebec, Canada Department of Neurology, University of California, Davis, California, U.S.A. University of California, Los Angeles, California, U.S.A. VA GLAHS - West Los Angeles, California, U.S.A.
Epilepsia. 2010 Dec;51 Suppl 5(0 5):1-5. doi: 10.1111/j.1528-1167.2010.02792.x.
In 1969, H.H. Jasper, A.A. Ward, and A. Pope and the Public Health Service Advisory Committee on the Epilepsies of the National Institutes of Health (NIH) published the first edition on Basic Mechanisms of the Epilepsies (BME). Since then, basic and clinical researchers in epilepsy have gathered together each decade to assess where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third edition of BME was named in honor of H.H. Jasper. Projected for publication in 2011, the fourth edition of Jasper's BME will (1) synthesize the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures; (2) examine the molecular, cellular, and network plasticity mechanisms that subserve excitability, seizure susceptibility, and ultimately epileptogenesis; (3) provide a framework for expanding the genome of rare mendelian epilepsies and understanding the complex heredity responsible for common epilepsies; (4) explore cellular mechanisms of the two main groups of presently known Mendelian epilepsy genes, namely ion channelopathies and developmental epilepsy genes; and (5) for the first time, describe the current efforts to translate the discoveries in epilepsy disease mechanisms into molecular and cellular therapeutic strategies in order to repair and cure the epilepsies. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at http://www.ncbi.nlm.nih.gov/books).
1969 年，H.H.贾斯珀、A.A.沃德、A.波普和美国国立卫生研究院（NIH）公共卫生服务癫痫咨询委员会出版了第一版《癫痫的基本机制》（BME）。从那时起，癫痫的基础和临床研究人员每十年聚集一次，评估癫痫研究的进展、取得的成就以及应该前进的方向。1999 年，第三版 BME 以 H.H.贾斯珀的名字命名。预计于 2011 年出版的第四版 Jasper 的 BME 将（1）综合神经元、突触和神经胶质之间相互作用在癫痫发作的起始、传播和终止中的作用；（2）研究促进兴奋性、癫痫易感性和最终癫痫形成的分子、细胞和网络可塑性机制；（3）为扩展罕见孟德尔癫痫的基因组和理解导致常见癫痫的复杂遗传提供框架；（4）探索目前已知的孟德尔癫痫基因的两个主要群体的细胞机制，即离子通道病和发育性癫痫基因；（5）首次描述将癫痫疾病机制的发现转化为分子和细胞治疗策略的当前努力，以便修复和治愈癫痫。有关该主题的扩展治疗，请参阅由牛津大学出版社出版的 Jasper 的《癫痫的基本机制，第四版》（Noebels JL、Avoli M、Rogawski MA、Olsen RW、Delgado-Escueta AV 编）（可在国家医学图书馆书架上的国家生物技术信息中心（NCBI）上获得，网址为 http://www.ncbi.nlm.nih.gov/books）。
