Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA.
Cancer Cell. 2012 Jul 10;22(1):3-4. doi: 10.1016/j.ccr.2012.06.010.
In this issue of Cancer Cell, Hu et al. report that TMPK and RNR, two key enzymes in deoxyribonucleotide biosynthesis, co-localize to damaged DNA and produce nucleotides necessary for DNA repair while suppressing uracil incorporation. TMPK inhibition disrupts this balance and selectively sensitizes cancer cells to low-dose chemotherapy.
在本期《癌细胞》杂志中，胡等人报告称，脱氧核苷酸生物合成中的两个关键酶 TMPK 和 RNR 可共同定位于受损的 DNA 上，并产生修复 DNA 所必需的核苷酸，同时抑制尿嘧啶掺入。TMPK 抑制破坏了这种平衡，使癌细胞对低剂量化疗更敏感。
