Field of Biochemistry and Molecular Cell Biology, Cornell University, Ithaca New York 14850, USA.
Nat Rev Cancer. 2013 Aug;13(8):572-83. doi: 10.1038/nrc3557. Epub 2013 Jul 4.
One-carbon metabolism involving the folate and methionine cycles integrates nutritional status from amino acids, glucose and vitamins, and generates diverse outputs, such as the biosynthesis of lipids, nucleotides and proteins, the maintenance of redox status and the substrates for methylation reactions. Long considered a 'housekeeping' process, this pathway has recently been shown to have additional complexity. Genetic and functional evidence suggests that hyperactivation of this pathway is a driver of oncogenesis and establishes a link to cellular epigenetic status. Given the wealth of clinically available agents that target one-carbon metabolism, these new findings could present opportunities for translation into precision cancer medicine.
一碳代谢涉及叶酸和蛋氨酸循环，整合了来自氨基酸、葡萄糖和维生素的营养状况，并产生了多种产物，如脂质、核苷酸和蛋白质的生物合成、氧化还原状态的维持以及甲基化反应的底物。长期以来，该途径一直被认为是一种“管家”过程，但最近的研究表明，它具有额外的复杂性。遗传和功能证据表明，该途径的过度激活是致癌的驱动因素，并建立了与细胞表观遗传状态的联系。鉴于目前有大量针对一碳代谢的临床可用药物，这些新发现可能为转化为精准癌症医学提供机会。
