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Molecular and cytogenetic studies of a patient with Philadelphia-negative, BCR-positive chronic myeloid leukemia and t(12;12)(q13;p12).

作者信息

Zaccaria A, Testoni N, Tassinari A, Celso B, Emanuel B S, Budarf M, Saglio G, Guerrasio A, Barletta C, Peschle C

机构信息

Centro di Genetica e Citogenetica Oncologica, Istituto di Ematologia, L. e A. Seràgnoli, Università di Bologna, Italy.

出版信息

Genes Chromosomes Cancer. 1990 Mar;1(4):284-8. doi: 10.1002/gcc.2870010405.

DOI:10.1002/gcc.2870010405
PMID:2278960
Abstract

A patient with Philadelphia (Ph1)-negative, breakpoint cluster region (bcr)-positive chronic myeloid leukemia (CML) is reported. Pulsed-field gel electrophoretic analysis demonstrated the comigration of both ABL and BCR sequences on the same BssHII and SacII fragment. Moreover, in situ hybridization studies demonstrated that ABL sequences had been moved from band 9q34 to 22q11 and that the additional t(12;12)(q13;p12) was not involved in the ABUBCR related translocation. Nevertheless, a possible role of oncogenes or regulatory sequences activated or inhibited by the additional translocation cannot be excluded.

摘要

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