一种新型的用于非束缚松鼠猴行为研究的触摸敏感仪器。
A novel touch-sensitive apparatus for behavioral studies in unrestrained squirrel monkeys.
机构信息
Preclinical Pharmacology Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.
出版信息
J Neurosci Methods. 2012 Aug 15;209(2):331-6. doi: 10.1016/j.jneumeth.2012.06.028. Epub 2012 Jul 10.
Abstract
Despite the increasing sophistication and affordability of touch-sensitive technology, its use in the behavioral sciences has been limited. The present paper describes the design and empirical validation of a novel touch-sensitive operant conditioning chamber for use with unrestrained squirrel monkeys. In addition, results from a variant of a commonly employed animal model of learning, the repeated acquisition task, demonstrate the effectiveness of this chamber in programming an assay of complex behavior. Finally, results from a study with Δ(9)-tetrahydrocannabinol, the active ingredient in marijuana, show that its effects in this novel touchscreen chamber were consistent with its dose-related effects on learning using more conventional approaches. Overall, these studies indicate the touchscreen apparatus provides effective means for programming complex behavioral tasks to assess the effects of pharmacological agents on cognitive function.
摘要
尽管触感灵敏技术日益复杂和价格合理，但它在行为科学中的应用却受到限制。本文介绍了一种新型触感灵敏操作性条件反射室的设计和实证验证，该设备可用于无约束的松鼠猴。此外，一种常用的学习动物模型——重复获取任务的变体的结果表明，该室在编程复杂行为分析方面非常有效。最后，一项涉及大麻中有效成分Δ(9)-四氢大麻酚的研究表明，它在新型触摸屏室中的作用与其在使用更传统方法评估学习方面的剂量相关作用一致。总体而言，这些研究表明，触摸屏设备为编程复杂行为任务提供了有效的手段，可用于评估药物对认知功能的影响。
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