Miyashita Tomoyuki, Kobayashi Zen, Numasawa Yoshiyuki, Akaza Miho, Ishihara Shoichiro, Shintani Shuzo
Department of Neurology, JA Toride Medical Center, Japan.
Intern Med. 2012;51(13):1755-7. doi: 10.2169/internalmedicine.51.7739. Epub 2012 Jul 1.
A 42-year-old man presented with fever, headache and liver dysfunction, and was diagnosed as having aseptic meningitis by lumbar puncture. The PCR detected Epstein-Barr virus (EBV)-DNA in the peripheral blood and cerebrospinal fluid. About 20 days after onset, the patient presented with hearing impairment in the right ear, which was confirmed by a pure tone audiogram. The hearing acuity improved after the initiation of hydrocortisone sodium phosphate. We presume that the hearing impairment was due to auditory nerve neuritis related to extension of inflammation of the meninges. This is the first reported case of EBV-associated meningitis showing hearing impairment.
一名42岁男性出现发热、头痛和肝功能障碍，经腰椎穿刺诊断为无菌性脑膜炎。聚合酶链反应（PCR）在外周血和脑脊液中检测到爱泼斯坦-巴尔病毒（EBV）-DNA。发病约20天后，患者出现右耳听力障碍，纯音听力图证实了这一点。使用磷酸氢化可的松后听力有所改善。我们推测听力障碍是由于与脑膜炎症扩展相关的听神经炎所致。这是首例报道的伴有听力障碍的EBV相关性脑膜炎病例。
