Jennane Selim, Mahtat El Mehdi, Konopacki Johanna, Foissaud Vincent, Souleau Bertrand, Malfuson Jean Valère, De Revel Thierry
Service d'hématologie clinique, Hôpital militaire d'instruction Mohammed V, Rabat, Maroc.
Ann Biol Clin (Paris). 2013 May-Jun;71(3):341-4. doi: 10.1684/abc.2013.0814.
The significance of Epstein-Barr virus detection in the cerebrospinal fluid of patients with Burkitt lymphoma is poorly studied. We report the case of a patient with immunodeficiency associated Burkitt lymphoma in complete remission who presented 5 months after the end of treatment, an isolated optic neuritis. Lumbar puncture found lymphocytic meningitis and the viral load of Epstein-Barr virus was 234,000 copies per milliliter in the cerebrospinal fluid. These symptoms could be explained by Epstein-Barr virus meningoencephalitis but the detection of MYC rearrangements in the cerebrospinal fluid confirms the diagnosis of Burkitt lymphoma cerebral relapse. The detection of the Epstein-Barr virus DNA in the cerebrospinal fluid should be interpreted with caution.
在伯基特淋巴瘤患者脑脊液中检测爱泼斯坦-巴尔病毒的意义鲜少被研究。我们报告了一例免疫缺陷相关伯基特淋巴瘤患者的病例，该患者在治疗结束5个月后完全缓解，出现了孤立性视神经炎。腰椎穿刺发现淋巴细胞性脑膜炎，脑脊液中爱泼斯坦-巴尔病毒的病毒载量为每毫升234,000拷贝。这些症状可能由爱泼斯坦-巴尔病毒脑膜脑炎解释，但脑脊液中MYC重排的检测证实了伯基特淋巴瘤脑复发的诊断。脑脊液中爱泼斯坦-巴尔病毒DNA的检测应谨慎解读。
