Fukushima Kiyoharu, Nakatsubo Michiko, Noda Masahiro, Uenami Takeshi, Hayama Yoshitomo, Tsuruta Naotoshi, Oniki Shuntaro, Saito Yoshiyuki, Niju Takashi, Ikeda Toshiyuki
Department of Internal Medicine, Nishinomiya Municipal Central Hospital, Japan.
Intern Med. 2012;51(13):1769-72. doi: 10.2169/internalmedicine.51.7530. Epub 2012 Jul 1.
Fluoroquinolones are widely used in the management of infectious diseases, and are generally safe and well tolerated. However, immediate hypersensitivity reactions, including anaphylactic reactions, have been reported. We present here a case of anaphylactic shock in a 26-year-old man following intravenous levofloxacin administration. Skin tests confirmed an immediate hypersensitivity reaction to levofloxacin. Subsequent oral challenge tests for garenoxacin, which showed negative skin test results, confirmed that garenoxacin was well tolerated. This is the first report of tolerance to full-dose garenoxacin in a patient who developed an immediate hypersensitivity reaction to levofloxacin.
氟喹诺酮类药物广泛用于传染病的治疗，总体上安全且耐受性良好。然而，已有报告称会出现包括过敏反应在内的速发型超敏反应。我们在此报告一例26岁男性静脉注射左氧氟沙星后发生过敏性休克的病例。皮肤试验证实对左氧氟沙星存在速发型超敏反应。随后对加替沙星进行的口服激发试验显示皮肤试验结果为阴性，证实加替沙星耐受性良好。这是首例对左氧氟沙星发生速发型超敏反应的患者对全剂量加替沙星耐受的报告。
