Desmedt E J, Henry O A, Beischer N A
University Department of Obstetrics and Gynaecology, Mercy Maternity Hospital, East Melbourne, Australia.
Br J Obstet Gynaecol. 1990 Dec;97(12):1115-22. doi: 10.1111/j.1471-0528.1990.tb02499.x.
During the 10-year period 1 January 1979 to 31 December 1988, polyhydramnios occurred in 537 patients with singleton pregnancies delivered at the Mercy Maternity Hospital. Associated maternal and fetal complications and the perinatal outcome of these pregnancies with polyhydramnios were analysed. In 248 of the 537 pregnancies (46%) in this group there were no maternal complications or fetal malformations and the perinatal mortality (PNM) rate was 2.4%. The PNM rate increased significantly to 13.1% when there was associated pre-eclampsia, 10% with gestational diabetes, and to 7.6% with miscellaneous complications. When polyhydramnios was associated with a fetal or placental malformation the PNM rate was 61.4%. The commonest malformations were central nervous system (31%), musculoskeletal (12%) and gastrointestinal system anomalies (10%). Placental chorioangioma occurred in two patients (0.4%) and both babies died. In women with low oestriol excretion (18% of the 455 tested) the PNM rate increased five times to 22.7%.
在1979年1月1日至1988年12月31日的10年期间，537名单胎妊娠产妇在慈悲妇产医院分娩时出现羊水过多。对这些羊水过多妊娠的相关母体和胎儿并发症以及围产期结局进行了分析。该组537例妊娠中有248例（46%）既无母体并发症也无胎儿畸形，围产儿死亡率（PNM）为2.4%。当合并先兆子痫时，PNM率显著升至13.1%；合并妊娠期糖尿病时为10%；合并其他并发症时为7.6%。当羊水过多与胎儿或胎盘畸形相关时，PNM率为61.4%。最常见的畸形是中枢神经系统（31%）、肌肉骨骼系统（12%）和胃肠道系统异常（10%）。两名患者（0.4%）发生胎盘绒毛膜血管瘤，两名婴儿均死亡。在雌三醇排泄量低的女性中（455例受检者中的18%），PNM率增至5倍，达22.7%。
