Rivera V M, Greenberg M E
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115.
New Biol. 1990 Sep;2(9):751-8.
Many growth factor-inducible immediate-early genes, including c-fos, encode transcription factors that are believed to propagate the mitogenic signal by activating a program of gene expression critical for cell proliferation. This review summarizes work aimed at elucidating the molecular mechanisms by which a growth factor-induced signal effects a change in gene expression. In the case of c-fos, both the activation and repression of transcription are mediated by the serum response element, a dyad symmetrical sequence found upstream of the c-fos gene. This element binds a complex of proteins, a component(s) of which may be the target of the growth factor-induced signal. Recent progress made towards understanding the roles of these factors in the regulation of c-fos transcription will be described.
许多生长因子诱导的即早基因，包括c-fos，编码转录因子，据信这些转录因子通过激活对细胞增殖至关重要的基因表达程序来传递促有丝分裂信号。本综述总结了旨在阐明生长因子诱导信号影响基因表达变化的分子机制的研究工作。就c-fos而言，转录的激活和抑制均由血清反应元件介导，血清反应元件是在c-fos基因上游发现的一个二元对称序列。该元件结合一种蛋白质复合物，其中的一个或多个组分可能是生长因子诱导信号的作用靶点。将描述在理解这些因子在c-fos转录调控中的作用方面取得的最新进展。
