Rizzo G, Arduini D, Romanini C, Mancuso S
Department of Obstetrics and Gynecology, S. Cuore Catholic University, Rome, Italy.
Biol Neonate. 1990;58(3):127-32. doi: 10.1159/000243251.
In order to assess whether maternal hyperoxygenation induces modifications of Doppler-measured velocity waveforms across atrioventricular valves, 15 healthy and 15 growth-retarded fetuses were studied in basal conditions and during the maternal administration of 60% humidified oxygen. Recordings were performed at 5-min intervals before, during and after maternal oxygen administration. In basal conditions, growth-retarded fetuses exhibited significantly lower ratios between the velocities during early passive ventricular filling and active ventricular filling (E/A ratio) at the level of both mitral and tricuspid valves when compared to healthy fetuses. Furthermore in healthy fetuses the velocity time integral across the tricuspid valve always slightly exceeded that across the mitral valve, whilst growth-retarded fetuses showed an inversed ratio between these velocities. During oxygen administration no changes were found between the two groups of fetuses with regard to the E/A ratios. Similarly the velocity time integrals were unaffected by oxygen administration in the healthy fetuses. Besides growth-retarded fetuses exhibited significant temporary modifications during oxygen administration as expressed by an increase in the velocity time integral across the mitral valve associated with a decrease of that across the tricuspid. These changes result in an inversion of the ratio between transtricuspid and transmitral velocity time integrals reaching values similar to those of healthy fetuses. Short-term oxygen administration affects the intracardiac flow redistribution present in growth-retarded fetuses bringing it to a pattern similar to that of healthy fetuses whereas the E/A ratios were not affected by the treatment.
为了评估母体高氧是否会引起经房室瓣多普勒测量的速度波形改变，对15例健康胎儿和15例生长受限胎儿在基础状态下以及母体吸入60%湿化氧期间进行了研究。在母体吸氧前、吸氧期间和吸氧后，每隔5分钟进行一次记录。在基础状态下，与健康胎儿相比，生长受限胎儿在二尖瓣和三尖瓣水平的早期被动心室充盈与主动心室充盈期间的速度比值（E/A比值）显著降低。此外，在健康胎儿中，经三尖瓣的速度时间积分总是略超过经二尖瓣的速度时间积分，而生长受限胎儿则显示出这些速度之间的相反比值。在吸氧期间，两组胎儿的E/A比值没有变化。同样，健康胎儿的速度时间积分不受吸氧影响。此外，生长受限胎儿在吸氧期间表现出明显的暂时改变，表现为经二尖瓣的速度时间积分增加，同时经三尖瓣的速度时间积分减少。这些变化导致三尖瓣与二尖瓣速度时间积分比值倒置，达到与健康胎儿相似的值。短期吸氧会影响生长受限胎儿存在的心内血流重新分布，使其呈现出与健康胎儿相似的模式，而E/A比值不受该治疗影响。
