Benson Henry Institute, Massachusetts General Hospital, Boston, USA.
Am J Phys Med Rehabil. 2012 Oct;91(10):863-70. doi: 10.1097/PHM.0b013e31825f1a67.
This study examined the feasibility, safety, and efficacy of using tai chi for treating major depressive disorder.
Thirty-nine Chinese Americans with major depressive disorder were randomized into a 12-wk tai chi intervention or a waitlisted control group in a 2:1 ratio. The key outcome measurement was the 17-item Hamilton Rating Scale for Depression. Positive response was defined as a decrease of 50% or more on the 17-item Hamilton Rating Scale for Depression, and remission was defined as a score of 7 or lower on the 17-item Hamilton Rating Scale for Depression.
Of the participants (n = 39), 77% were women, and mean (SD) age was 55 (10) years. There were 26 (67%) participants in the tai chi intervention group and 13 (33%) in the control group. Of the participants in the tai chi group, 73% completed the intervention; no adverse events were reported. We observed trends toward improvement in the tai chi intervention group, compared with the control group, in positive treatment-response rate (24% vs. 0%) and remission rate (19% vs. 0%), although the differences in our small sample did not reach statistical significance.
A randomized controlled trial of tai chi is feasible and safe in Chinese American patients with major depressive disorder. These promising pilot study results inform the design of a more definitive trial.
本研究旨在探讨太极拳治疗重度抑郁症的可行性、安全性和疗效。
39 名美籍华人重度抑郁症患者按 2:1 的比例随机分为 12 周太极拳干预组或候补对照组。主要结局测量指标为 17 项汉密尔顿抑郁量表。阳性反应定义为 17 项汉密尔顿抑郁量表评分下降 50%或更多，缓解定义为 17 项汉密尔顿抑郁量表评分 7 或更低。
参与者（n=39）中，77%为女性，平均（SD）年龄为 55（10）岁。26 名（67%）参与者在太极拳干预组，13 名（33%）在对照组。太极拳组中，73%的参与者完成了干预；未报告不良事件。与对照组相比，太极拳干预组在阳性治疗反应率（24%比 0%）和缓解率（19%比 0%）方面均有改善趋势，但我们的小样本差异没有达到统计学意义。
太极拳对美籍华人重度抑郁症患者是可行和安全的。这些有希望的初步研究结果为更明确的试验设计提供了信息。
