硝苯地平和利奥地平对完整红细胞生化过程的影响
[Effects of nifedipine and riodipine on biochemical processes in intact erythrocytes].
作者信息
Tirzite D Ia, Tirzit G D, Dubur G Ia
出版信息
Biull Eksp Biol Med. 1990 Oct;110(10):379-81.
PMID:2279087
Abstract
Cardiovascular drugs nifedipine and riodipine (1,4-dihydropyridine derivatives) were studied as to their effect on some biochemical characteristics of erythrocytes. Both compounds failed to effect 2,3-diphosphoglycerate concentration in intact erythrocytes, but slightly decreased the level of adenosinetriphosphate. The drugs inhibited the process of acid hemolysis, this inhibition being particularly manifest in the case of nifedipine.
摘要
对心血管药物硝苯地平和硫氮卓（1,4 - 二氢吡啶衍生物）对红细胞某些生化特性的影响进行了研究。这两种化合物均未影响完整红细胞中2,3 - 二磷酸甘油酸的浓度，但略微降低了三磷酸腺苷的水平。这些药物抑制了酸溶血过程，这种抑制在硝苯地平的情况下尤为明显。
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