直接氟化酚酞：一种用于体内 pH 值测量的正电子发射示踪剂的合成方法。
Direct fluorination of phenolsulfonphthalein: a method for synthesis of positron-emitting indicators for in vivo pH measurement.
机构信息
Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 195 John Morgan Building, Philadelphia, PA 19104-6072, USA.
出版信息
Cell Biochem Biophys. 2013 May;66(1):1-5. doi: 10.1007/s12013-012-9390-x.
Abstract
We report a reaction of direct electrophilic fluorination of phenolsulfonphthalein at mild conditions. This reaction affords the synthesis of novel positron-emitting (18)F-labeled pH indicators. These compounds are useful for non-invasive in vivo pH measurement in biological objects.
摘要
我们报道了在温和条件下酚磺酞的直接亲电氟化反应。该反应提供了新型正电子发射（18）F 标记的 pH 指示剂的合成方法。这些化合物可用于生物体内的非侵入性 pH 测量。
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