Using HF as a Source of Fluorine in Kitamura's Electrophilic Fluorination.

Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China.

Oakwood Chemical, Inc. 730 Columbia Hwy. N, Estill, SC 29918, USA.

Molecules. 2020 Apr 30;25(9):2116. doi: 10.3390/molecules25092116.

This review article focused on the innovative procedure for electrophilic fluorination using HF and in situ generation of the required electrophilic species derived from hypervalent iodine compounds. The areas of synthetic application of this approach include fluorination of 1,3-dicarbonyl compounds, aryl-alkyl ketones, styrene derivatives, α,β-unsaturated ketones and alcohols, homoallyl amine and homoallyl alcohol derivatives, 3-butenoic acids and alkynes.

这篇综述文章重点介绍了使用 HF 的亲电氟化的创新方法，以及从高价碘化合物原位生成所需亲电物种的方法。这种方法的合成应用领域包括 1,3-二羰基化合物、芳基烷基酮、苯乙烯衍生物、α,β-不饱和酮和醇、偕胺和偕烯醇衍生物、3-丁烯酸和炔烃的氟化。