Lermontova N N, Soliakov L S, Bachurin S O, Serkova T P, Petrova L N, Dranyĭ O A, Tkachenko S E, Kalashnikov V V
Biull Eksp Biol Med. 1990 Oct;110(10):397-9.
Possibility of ortho-, para-, meta-methylphenyl and methoxyphenyl-derivates of MPTP to produce parkinsonism was investigated. Only ortho-methylphenyl- and ortho-methoxyphenyl-derivates of MPTP cause a persistent loss in dopamine content in the brain and produced the clinical symptoms of parkinsonism. All substances produced Parkinsonian-like syndrome gives the symptoms of activation of nervous system during 0.5-1 h after injection and symptoms of depression in following 3 h of observations.
研究了MPTP的邻、对、间甲基苯基和甲氧基苯基衍生物产生帕金森症的可能性。只有MPTP的邻甲基苯基和邻甲氧基苯基衍生物会导致大脑中多巴胺含量持续减少，并产生帕金森症的临床症状。所有产生帕金森样综合征的物质在注射后0.5 - 1小时内出现神经系统激活症状，在随后3小时的观察中出现抑郁症状。
