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1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的帕金森病小鼠纹状体的胺荧光组织化学研究

Amine fluorescence histochemical investigation of the striatum in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced parkinsonian mice.

作者信息

Mizukawa K, Ogawa N, Sora Y H

机构信息

Department of Anatomy, Okayama University Medical School, Japan.

出版信息

Res Commun Chem Pathol Pharmacol. 1988 Jan;59(1):121-8.

PMID:3258432
Abstract

Treatment of mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) markedly decreased dopamine fluorescence in the lateral part of the striatum but not in the median part of the striatum. However, dopamine fluorescence in lateral part of the striatum recovered by treatment L-dihydroxyphenylalanine(L-DOPA).

摘要

用1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）处理小鼠，显著降低了纹状体外侧部分的多巴胺荧光，但纹状体中间部分未受影响。然而，通过左旋多巴（L-DOPA）治疗，纹状体外侧部分的多巴胺荧光得以恢复。

相似文献

1
Amine fluorescence histochemical investigation of the striatum in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced parkinsonian mice.1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的帕金森病小鼠纹状体的胺荧光组织化学研究
Res Commun Chem Pathol Pharmacol. 1988 Jan;59(1):121-8.
2
[A mouse model of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced parkinsonism: effect of norepinephrine terminal destruction].[N-甲基-4-苯基-1,2,3,6-四氢吡啶诱导的帕金森病小鼠模型：去甲肾上腺素能终末破坏的影响]
No To Shinkei. 1987 Jul;39(7):663-72.
3
[The effect of prolonged parenteral administration of liposomes and L-Dopa incorporated into liposomes on metabolism of dopamine and its metabolites in the striatum of mice with experimental parkinsonian syndrome].[长期肠胃外给予脂质体及包载于脂质体中的左旋多巴对实验性帕金森综合征小鼠纹状体中多巴胺及其代谢产物代谢的影响]
Biull Eksp Biol Med. 1997 Feb;123(2):150-3.
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l-dopa-induced reversal in striatal glutamate following partial depletion of nigrostriatal dopamine with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.用1-甲基-4-苯基-1,2,3,6-四氢吡啶部分耗尽黑质纹状体多巴胺后左旋多巴诱导的纹状体谷氨酸逆转。
Neuroscience. 2005;136(1):333-41. doi: 10.1016/j.neuroscience.2005.08.003. Epub 2005 Sep 28.
5
The effects of chronic levodopa treatment on pre- and postsynaptic markers of dopaminergic function in striatum of parkinsonian monkeys.慢性左旋多巴治疗对帕金森病猴纹状体中多巴胺能功能的突触前和突触后标志物的影响。
Mov Disord. 1997 Mar;12(2):148-58. doi: 10.1002/mds.870120204.
6
Interference of 3-O-methyldopa with L-dopa treatment for MPTP-induced parkinsonism in mice.
Adv Neurol. 1990;53:225-9.
7
[Study of extracellular concentration of dopamine and its metabolites in mice striatum by a microdialysis technique at intraperitoneal administration of MPTP].
Zh Vyssh Nerv Deiat Im I P Pavlova. 2010 Jan-Feb;60(1):109-19.
8
Chronic L-deprenyl does not alter the restoration of striatal dopamine in MPTP-lesioned mice.
J Neurosci Res. 1989 Jul;23(3):326-9. doi: 10.1002/jnr.490230312.
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A simple quantitative bradykinesia test in MPTP-treated mice.在经MPTP处理的小鼠中进行的一项简单定量运动迟缓测试。
Res Commun Chem Pathol Pharmacol. 1985 Dec;50(3):435-41.
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Reduction of muscarinic cholinergic receptors in mouse striatum by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its recovery by levodopa treatment.1-甲基-4-苯基-1,2,3,6-四氢吡啶对小鼠纹状体毒蕈碱胆碱能受体的减少作用及其左旋多巴治疗后的恢复情况。
Res Commun Chem Pathol Pharmacol. 1987 Jul;57(1):133-6.

引用本文的文献

1
Muscarinic cholinergic receptor-mediated modulation on striatal c-fos mRNA expression induced by levodopa in rat brain.毒蕈碱型胆碱能受体对左旋多巴诱导的大鼠脑纹状体c-fos mRNA表达的介导调节作用。
J Neural Transm Gen Sect. 1992;90(3):171-81. doi: 10.1007/BF01250959.