共检测在重症手足口病发病机制中的作用。
Co-detection in the pathogenesis of severe hand-foot-mouth disease.
机构信息
Institute of Health Quarantine, Chinese Academy of Inspection and Quarantine, Beijing 100123, People's Republic of China.
出版信息
Arch Virol. 2012 Nov;157(11):2219-22. doi: 10.1007/s00705-012-1396-6. Epub 2012 Jul 13.
Abstract
It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that EV71 was significantly associated with severe-HFMD patients. Co-detection of EV71 with norovirus and rotavirus was also significantly associated with severe-HFMD patients: The OR (95 % CI) value was 6.466 (2.735, 15.283) and 7.561 (3.560, 16.057), p < 0.001, respectively. Co-detection of EV71 with rotavirus or norovirus is probably associated with severe HFMD.
摘要
尚不清楚肠道病毒 71 型（EV71）与其他肠道病毒共同检出是否在重症手足口病（HFMD）的发病机制中起作用。对临床诊断为轻症和重症 HFMD 的 680 份粪便标本进行了 EV71、CA16、诺如病毒、博卡病毒和轮状病毒检测。结果显示，EV71 与重症 HFMD 患者显著相关。EV71 与诺如病毒和轮状病毒共同检出也与重症 HFMD 患者显著相关：OR（95%CI）值分别为 6.466（2.735，15.283）和 7.561（3.560，16.057），p 值均 < 0.001。EV71 与轮状病毒或诺如病毒共同检出可能与重症 HFMD 相关。
相似文献
1
Co-detection in the pathogenesis of severe hand-foot-mouth disease.
Arch Virol. 2012 Nov;157(11):2219-22. doi: 10.1007/s00705-012-1396-6. Epub 2012 Jul 13.
2
[Detection of enterovirus 71 and coxsackievirus A16 from children with hand, foot and mouth disease in Shanghai, 2002].
Zhonghua Er Ke Za Zhi. 2005 Sep;43(9):648-52.
3
Characterization of severe hand, foot, and mouth disease in Shenzhen, China, 2009-2013.
J Med Virol. 2015 Sep;87(9):1471-9. doi: 10.1002/jmv.24200. Epub 2015 May 7.
4
5
Epidemiology Characteristics of Human Coxsackievirus A16 and Enterovirus 71 Circulating in Linyi, China, from 2009 to 2017.
Jpn J Infect Dis. 2018 Nov 22;71(6):470-473. doi: 10.7883/yoken.JJID.2018.035. Epub 2018 Jun 29.
6
Epidemic characteristics of hand, foot, and mouth disease in Shanghai from 2009 to 2010: Enterovirus 71 subgenotype C4 as the primary causative agent and a high incidence of mixed infections with coxsackievirus A16.
Scand J Infect Dis. 2012 Apr;44(4):297-305. doi: 10.3109/00365548.2011.634433. Epub 2011 Dec 18.
7
A new factor influencing pathogen detection by molecular assay in children with both mild and severe hand, foot, and mouth disease.
Diagn Microbiol Infect Dis. 2013 Jun;76(2):162-7. doi: 10.1016/j.diagmicrobio.2013.02.011. Epub 2013 Mar 25.
8
Intestinal detoxification time of hand-foot-and-mouth disease in children with EV71 infection and the related factors.
World J Pediatr. 2015 Nov;11(4):380-5. doi: 10.1007/s12519-015-0045-z. Epub 2015 Oct 11.
9
[Etiology surveillance of hand-foot-mouth disease in Henan province between 2008 and 2011].
Zhonghua Yu Fang Yi Xue Za Zhi. 2012 Oct;46(10):883-7.
10
Excretion of enterovirus 71 in persons infected with hand, foot and mouth disease.
Virol J. 2013 Jan 23;10:31. doi: 10.1186/1743-422X-10-31.
引用本文的文献
1
Clinico Virological Characterization of Hand, Foot and Mouth Disease in a Tertiary Care Hospital, South India.
J Glob Infect Dis. 2023 Feb 10;15(1):13-18. doi: 10.4103/jgid.jgid_145_22. eCollection 2023 Jan-Mar.
2
The first genome sequences of human bocaviruses from Vietnam.
Wellcome Open Res. 2017 Jan 9;1:16. doi: 10.12688/wellcomeopenres.10042.2. eCollection 2016.
3
Molecular epidemiology of human enterovirus 71 at the origin of an epidemic of fatal hand, foot and mouth disease cases in Cambodia.
Emerg Microbes Infect. 2016 Sep 21;5(9):e104. doi: 10.1038/emi.2016.101.
4
Coxsackievirus A16 infection stimulates imbalances of T cells in children.
Exp Ther Med. 2015 Jun;9(6):2213-2218. doi: 10.3892/etm.2015.2405. Epub 2015 Apr 3.
5
Co-circulation and genomic recombination of coxsackievirus A16 and enterovirus 71 during a large outbreak of hand, foot, and mouth disease in Central China.
PLoS One. 2014 Apr 28;9(4):e96051. doi: 10.1371/journal.pone.0096051. eCollection 2014.
6
A new factor influencing pathogen detection by molecular assay in children with both mild and severe hand, foot, and mouth disease.
Diagn Microbiol Infect Dis. 2013 Jun;76(2):162-7. doi: 10.1016/j.diagmicrobio.2013.02.011. Epub 2013 Mar 25.
7
Effect of meteorological variables on the incidence of hand, foot, and mouth disease in children: a time-series analysis in Guangzhou, China.
BMC Infect Dis. 2013 Mar 13;13:134. doi: 10.1186/1471-2334-13-134.
本文引用的文献
1
Norovirus encephalopathy in a previously healthy child.
Pediatr Infect Dis J. 2010 Nov;29(11):1057-9. doi: 10.1097/INF.0b013e3181e78889.
2
Two patients with acute rotavirus encephalitis associated with cerebellar signs and symptoms.
Eur J Pediatr. 2010 Oct;169(10):1287-91. doi: 10.1007/s00431-010-1202-y. Epub 2010 May 12.
3
Enterovirus 71: epidemiology, pathogenesis and management.
Expert Rev Anti Infect Ther. 2009 Aug;7(6):735-42. doi: 10.1586/eri.09.45.
4
Multiplex real-time RT-PCR for simultaneous detection of GI/GII noroviruses and murine norovirus 1.
J Virol Methods. 2009 Nov;161(2):247-53. doi: 10.1016/j.jviromet.2009.06.019. Epub 2009 Jun 27.
5
Acute encephalitis caused by intrafamilial transmission of enterovirus 71 in adult.
Emerg Infect Dis. 2008 May;14(5):828-30. doi: 10.3201/eid1405.071121.
6
Outbreak of neurologic enterovirus type 71 disease: a diagnostic challenge.
Clin Infect Dis. 2007 Oct 15;45(8):950-7. doi: 10.1086/521895. Epub 2007 Sep 13.
7
Rotavirus associated acute encephalitis/encephalopathy and concurrent cerebellitis: report of two cases.
Brain Dev. 2007 Nov;29(10):670-3. doi: 10.1016/j.braindev.2007.04.005. Epub 2007 May 29.
8
Neurodevelopment and cognition in children after enterovirus 71 infection.
N Engl J Med. 2007 Mar 22;356(12):1226-34. doi: 10.1056/NEJMoa065954.
9
Human bocavirus infection, People's Republic of China.
Emerg Infect Dis. 2007 Jan;13(1):165-8. doi: 10.3201/eid1301.060842.
10
Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study.
Clin Infect Dis. 2007 Mar 1;44(5):646-56. doi: 10.1086/511073. Epub 2007 Jan 22.
Zotero 插件