Allergy and Lung Clinic Helsingør, Denmark.
Acta Derm Venereol. 2012 Sep;92(5):475-9. doi: 10.2340/00015555-1389.
The prevalence of non-hereditary angioedema was investigated in a general population sample (n = 7,931) and in a sample of Danish patients (n = 7,433) tested for deficiency of functional complement C(1) esterase inhibitor protein (functional C(1) INH). The general population sample (44% response rate) reported a lifetime prevalence of 7.4% for angioedema. In both groups symptoms were most frequent in the lips, head, neck, eyes and tongue. In the C(1) INH test normal group angioedema was still active at the time of the study in 53% of the patients, and 36% reported symptoms in the throat, 23% in the abdominal area, 17% had diarrhoea, 11% had vomiting and 6% fainted during attacks. Non-hereditary angioedema has high lifetime prevalence and becomes chronic in approximately 50% of affected patients. Symptoms in the larynx and throat, as well as non-specific symptoms, such as dizziness and abdominal pain, were more frequent than previously reported.
在一个普通人群样本（n=7931）和一个丹麦患者样本（n=7433）中，对非遗传性血管性水肿的患病率进行了调查，这些患者接受了功能性补体 C(1)酯酶抑制剂蛋白（功能性 C(1)INH）缺乏症的检测。普通人群样本（44%的应答率）报告称，血管性水肿的终身患病率为 7.4%。在这两个群体中，症状最常发生在嘴唇、头部、颈部、眼睛和舌头。在 C(1)INH 测试正常组中，血管性水肿在研究时仍然活跃在 53%的患者中，36%的患者报告有喉咙症状，23%的患者有腹部症状，17%的患者腹泻，11%的患者呕吐，6%的患者在发作时晕倒。非遗传性血管性水肿的终身患病率较高，约有 50%的患者会发展为慢性疾病。喉部和喉部的症状，以及头晕和腹痛等非特异性症状，比之前报道的更为常见。
