Alkhalil Mohammad, Tate Stephen
Lagan Valley Hospital, Lisburn, UK.
BMJ Case Rep. 2010 Oct 21;2010:bcr1220092586. doi: 10.1136/bcr.12.2009.2586.
We report a case of probable iatrogenic vitamin K deficiency in the context of antibiotic treatment for endocarditis. The patient was initially admitted with breathlessness and treated for an exacerbation of chronic obstructive pulmonary disease. However, during this period the patient was further diagnosed with endocarditis following repeated temperature spikes. Following initiation of antibiotic treatment for endocarditis the patient was noted to become increasingly anaemic. The patient was noted to have prolonged prothrombin time despite no anticoagulants. Antibiotics have been reported to alter the gut flora causing vitamin K deficiency; thereby, resulting in coagulopathy. We give a brief overview and literature review regarding potential vitamin K deficiency in this clinical context.
我们报告了一例在因心内膜炎接受抗生素治疗过程中可能发生医源性维生素K缺乏的病例。患者最初因呼吸困难入院，接受慢性阻塞性肺疾病加重期的治疗。然而，在此期间，患者在反复出现体温峰值后被进一步诊断为心内膜炎。在心内膜炎抗生素治疗开始后，发现该患者贫血日益加重。尽管未使用抗凝剂，但发现该患者的凝血酶原时间延长。据报道，抗生素会改变肠道菌群，导致维生素K缺乏；从而引发凝血病。我们对这种临床背景下潜在的维生素K缺乏进行简要概述并进行文献综述。
