Division of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea.
Mediators Inflamm. 2012;2012:503128. doi: 10.1155/2012/503128. Epub 2012 Jun 25.
PGD(2) is formed from arachidonic acid by successive enzyme reactions: oxygenation of arachidonic acid to PGH(2), a common precursor of various prostanoids, catalyzed by cyclooxygenase, and isomerization of PGH(2) to PGD(2) by PGD synthases (PGDSs). PGD(2) can be either pro- or anti-inflammatory depending on disease process and etiology. The anti-inflammatory and immunomodulatory attributes of PGDS/PGD(2) provide opportunities for development of novel therapeutic approaches for resistant infections and refractory inflammatory diseases. This paper highlights the role of PGD synthases and PGD2 in immune inflammatory response.
PGD(2) 由花生四烯酸通过连续的酶反应形成：花生四烯酸被环加氧酶氧合形成 PGH(2)，PGH(2) 是各种前列腺素的共同前体，然后 PGD 合酶（PGDSs）将 PGH(2)异构化为 PGD(2)。PGD(2) 可以是促炎的也可以是抗炎的，这取决于疾病过程和病因。PGDS/PGD(2) 的抗炎和免疫调节特性为开发针对耐药感染和难治性炎症性疾病的新型治疗方法提供了机会。本文重点介绍了 PGD 合酶和 PGD2 在免疫炎症反应中的作用。
