Zhang Li Rita, Chiarelli Anna M, Glendon Gord, Mirea Lucia, Knight Julia A, Andrulis Irene L, Ritvo Paul
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5T 3L9.
J Cancer Epidemiol. 2012;2012:545062. doi: 10.1155/2012/545062. Epub 2012 Jun 28.
Background. Few prospective studies have examined associations between breast cancer worry and screening behaviours in women with elevated breast cancer risks based on family history. Methods. This study included 901 high familial risk women, aged 23-71 years, from the Ontario site of the Breast Cancer Family Registry. Self-reported breast screening behaviours at year-one followup were compared between women at low (N = 305), medium (N = 433), and high (N = 163) levels of baseline breast cancer worry using logistic regression. Nonlinear relationships were assessed using likelihood ratio tests. Results. A significant non-linear inverted "U" relationship was observed between breast cancer worry and mammography screening (P = 0.034) for all women, where women at either low or high worry levels were less likely than those at medium to have a screening mammogram. A similar significant non-linear inverted "U" relationship was also found among all women and women at low familial risk for worry and screening clinical breast examinations (CBEs). Conclusions. Medium levels of cancer worries predicted higher rates of screening mammography and CBE among high-risk women.
背景。很少有前瞻性研究探讨基于家族史有较高乳腺癌风险的女性中，乳腺癌担忧与筛查行为之间的关联。方法。本研究纳入了来自乳腺癌家族登记处安大略站点的901名高家族风险女性，年龄在23至71岁之间。使用逻辑回归比较了基线乳腺癌担忧程度低（N = 305）、中（N = 433）和高（N = 163）的女性在一年随访时自我报告的乳腺筛查行为。使用似然比检验评估非线性关系。结果。在所有女性中观察到乳腺癌担忧与乳房X线筛查之间存在显著的非线性倒“U”关系（P = 0.034），即担忧程度低或高的女性比担忧程度中等的女性进行乳房X线筛查的可能性更小。在所有女性以及担忧和筛查临床乳腺检查（CBE）家族风险低的女性中也发现了类似的显著非线性倒“U”关系。结论。中等程度的癌症担忧预示着高危女性中乳房X线筛查和CBE的比率更高。
