State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Chem Commun (Camb). 2012 Aug 28;48(67):8347-9. doi: 10.1039/c2cc32919k. Epub 2012 Jul 13.
In this work we studied how backbone chemical modifications, such as 2'-O-methyl, phosphorothioate, L-form nucleotides and locked nucleic acid, on G-quadruplex based DNAzymes would affect their peroxidase activity. Our results indicate that 2'-O-methyl modification facilitates the formation of a perfectly compacted parallel structure and significantly promotes peroxidase activity of G-quadruplex based DNAzymes.
在这项工作中，我们研究了基于 G-四链体的 DNA 酶的骨架化学修饰（如 2'-O-甲基、硫代磷酸酯、L 型核苷酸和锁核酸）如何影响其过氧化物酶活性。我们的结果表明，2'-O-甲基修饰有利于形成完全紧凑的平行结构，并显著促进基于 G-四链体的 DNA 酶的过氧化物酶活性。
