[Experimental study on in vitro transdermal absorption of Shangshi Zhitong cataplasm].
作者信息
Wu Xiaoru, He Cheng, Wang Naijie, Zhang Yuanyuan, Xi Chunxia, Xie Suhua
机构信息
State Research Center for Research and Development of Traditional Chinese Medicine Multi-ingredient Drugs, Beijing 100075, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2012 Apr;37(7):913-5.
OBJECTIVE
To conduct an experimental study on in vitro transdermal absorption of prepared Shangshi Zhitong cataplasm.
METHOD
Franz diffusing cells and mice were adopted for the percutaneous penetration study. The accumulative percutaneous permeation of total alkaloids, strychnine and atropine in certain time was determined by acid dye colorimetry and HPLC.
RESULT
The accumulative permeation of alkaloids (Q) increased with time (t), with a linear relation between them.
CONCLUSION
The in vitro percutaneous penetration of Shangshi Zhitong cataplasm complies with the zero-order kinetics.
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