[不同基质上伤湿止痛贴的经皮渗透研究]
[Percutaneous permeability study for patches Shangshi Zhitong on different kinds of bases].
作者信息
Yan Xiaoping, Guan Shijie, Zheng Rui, Yi Bowen, Wang Yonggang, Zhu Yonghong
机构信息
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2011 Nov;36(21):2960-2.
OBJECTIVE
To study the percutaneous permeability of patches Shangshi Zhitong on different kinds of bases with the permeation percentage of brucine, strychnine and atropine.
METHOD
Using modified Franz difusion to investigate the penetration quantity of brucine, strychnine and atropine. The contents of brucine, strychnine and atropine were determined by HPLC.
RESULT
The average accumulative permeation percentage of brucine, strychnine and atropine on new base were 53.25%, 74.52% were 34.32%, respectively, and on old base are 54.90%, 50.24%, 46. 54%, respectively.
CONCLUSION
The new base benefits the lipophilic drugs and releases more stably.
目的
以马钱子碱、士的宁和阿托品的渗透百分率为指标，研究伤湿止痛贴剂在不同基质上的经皮渗透性。
方法
采用改良的Franz扩散池法考察马钱子碱、士的宁和阿托品的透过量，用高效液相色谱法测定马钱子碱、士的宁和阿托品的含量。
结果
马钱子碱、士的宁和阿托品在新基质上的平均累积渗透百分率分别为53.25%、74.52%、34.32%，在旧基质上分别为54.90%、50.24%、46.54%。
结论
新基质有利于脂溶性药物，释放更稳定。
Zotero 插件