Wang Yiwei, Li Yujie, Wang Yanli, Yang Weipeng, Chen Ying, Zhang Dong, Yang Qing, Zhang Yingfeng, Li Tao, Zhu Xiaoxin
China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2012 Apr;37(7):985-90.
To observe the impact on absorption of berberine and palmatine in different compatibilities of Wuji pill by the perfused rat intestine-liver preparation.
Use L9 (3(4)) orthogonal design table, establish the perfused rat intestine-liver preparation, the twelve Wuji pill compatibilities duodenal administrated, collect the perfusate at different times points for LC-MS detection, calculate the absorbed score, Ka.
Evodiae Fructus and the absorption score, Ka of berberine and palmatine are inverse correlated. The most superior portion which promote the absorption is Coptidis Rhizoma-Evodiae Fructus-Paeoniae Radix Alba 3:1:3.
Evodiae Fructus suppressed the absorption of berberine and palmatine. With the different portion the absorption also have big different.
采用大鼠肠-肝灌流制备方法，观察不同配伍的乌鸡丸对小檗碱和巴马汀吸收的影响。
采用L9(3(4))正交设计表，建立大鼠肠-肝灌流制备方法，十二指肠给予12种乌鸡丸配伍组方，于不同时间点收集灌流液进行LC-MS检测，计算吸收分数、Ka。
吴茱萸与小檗碱、巴马汀的吸收分数、Ka呈负相关。促进吸收的最佳组方为黄连-吴茱萸-白芍3∶1∶3。
吴茱萸抑制小檗碱和巴马汀的吸收。不同组方对吸收影响差异较大。
