Chen B F
Department of Pathology, Fujian Medical College.
Zhonghua Bing Li Xue Za Zhi. 1990 Sep;19(3):172-4.
Enzyme histochemistry and acridine orange (AO) fluorescence techniques were used for studying muscle biopsy specimens of progressive muscular dystrophy in 75 cases. Five characteristic pathologic patterns for diagnosis were summarized. The level of serum CPK was be used as a marker for judging necrotic fibers. The result of AO staining showed that the number of regenerating IIc type fibers in DMD increased by 5-20%. This indicates that the numbers of the IIc type fibers are also related to necrotic fibers. The authors consider that the regenerative course is a compensatory repair reaction on necrotic fibers. But clinically, the speed of necrosis development is much higher than that of regeneration. Thus, enhancing the synthesis of proteins and promoting the capacity of regeneration should be considered as a new approach to effective therapy for DMD patients.
采用酶组织化学和吖啶橙（AO）荧光技术对75例进行性肌营养不良患者的肌肉活检标本进行研究。总结出5种用于诊断的特征性病理模式。血清肌酸磷酸激酶（CPK）水平用作判断坏死纤维的标志物。AO染色结果显示，杜氏肌营养不良症（DMD）中再生的IIc型纤维数量增加了5% - 20%。这表明IIc型纤维的数量也与坏死纤维有关。作者认为，再生过程是对坏死纤维的一种代偿性修复反应。但在临床上，坏死发展的速度远高于再生速度。因此，增强蛋白质合成和促进再生能力应被视为治疗DMD患者的一种新的有效治疗方法。
