Lin X M
Pathology Department of Shanghai, No. 1 Hospital of PLA Air Force.
Zhonghua Bing Li Xue Za Zhi. 1990 Sep;19(3):204-6.
31 cases of primary hyperplasia and neoplasms of the parathyroid gland are reported. Among them, 23 cases were parathyroid adenoma, 6 cases parathyroid hyperplasia, one case adenoma associated with hyperplasia, and one case of parathyroid adenocarcinoma. Follow-up study demonstrated that prognosis in the adenoma group is better than that in the hyperplasia group, and one carcinoma patient died from metastasis. Regarding differential diagnosis, adenoma is usually single, with frequent presence of oppressed parathyroid tissue next to the tumor capsule; and cell atypical hyperplasia is often seen microscopically, which is usually multiple in sites, and some residual adipose tissue can be found under the microscope. Clinically, both groups manifested hypercalcemia and hypophosphatemia, especially in those cases with chief cell hyperplasia. Capsule infiltration and vascular embolism are emphasized as the differential features between benign and malignant parathyroid tumours.
报告了31例甲状旁腺原发性增生和肿瘤。其中，甲状旁腺腺瘤23例，甲状旁腺增生6例，腺瘤伴增生1例，甲状旁腺癌1例。随访研究表明，腺瘤组的预后优于增生组，1例癌患者死于转移。关于鉴别诊断，腺瘤通常为单发，肿瘤包膜旁常存在受压的甲状旁腺组织；显微镜下常可见细胞非典型增生，其部位通常为多发，显微镜下可发现一些残留脂肪组织。临床上，两组均表现为高钙血症和低磷血症，尤其是在主细胞增生的病例中。包膜浸润和血管栓塞被强调为良性和恶性甲状旁腺肿瘤的鉴别特征。
