Liporaci Junior Jorge Luiz Jacob
Maxillofacial Oral Surgeon; PhD, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, SP, Brazil.
Rev Bras Anestesiol. 2012 Jul;62(4):502-10. doi: 10.1016/S0034-7094(12)70148-4.
Literature on preemptive analgesia is controversial. Reliability of results and difficult reproducibility of research contribute for non-elucidation of the subject. The aim of this study is to test the efficacy of oral ketoprofen (150 mg) preemptively administrated two days before third molar surgery, compared with postoperative administration in the same patient.
Thirteen patients underwent surgical removal of bilateral third molar in two separate procedures. In a random and double blind procedure, oral ketoprofen 150 mg was administered every 12 hours two days before surgery and, after the procedure, the same drug was administered for three days. On the other side, a control (placebo) was used orally every 12 hours two days before surgery and, after the procedure, ketoprofen 150 mg was administered every 12 hours for three days. Postoperative pain was assessed by visual analogue scale, nominal scale, and amount of rescue analgesics consumed.
There was no statistically significant difference in postoperative pain between the preemptive treatment and control.
In this experimental model, preemptive analgesia was not effective in reducing postoperative pain in surgical extraction of third molar compared with the postoperative administration of the same drug.
关于超前镇痛的文献存在争议。研究结果的可靠性以及研究难以重复导致该主题尚未阐明。本研究的目的是测试在第三磨牙手术前两天预防性给予口服酮洛芬（150毫克）的效果，并与同一患者术后给药进行比较。
13名患者分两次接受双侧第三磨牙的手术拔除。在随机双盲程序中，术前两天每12小时口服150毫克酮洛芬，术后同样的药物服用三天。另一方面，术前两天每12小时口服对照剂（安慰剂），术后每12小时口服150毫克酮洛芬，持续三天。通过视觉模拟量表、数字量表和所消耗的急救镇痛药数量评估术后疼痛。
超前治疗与对照之间术后疼痛无统计学显著差异。
在该实验模型中，与术后给予相同药物相比，超前镇痛在减少第三磨牙手术拔除术后疼痛方面无效。
