Pazyar Nader, Feily Amir, Yaghoobi Reza
Department of Dermatology, Jundishapur University of Medical Sciences, Ahvaz, Iran.
Curr Clin Pharmacol. 2012 Nov;7(4):271-5. doi: 10.2174/157488412803305821.
Interleukin (IL)-1 is a pivotal proinflammatory cytokine consisting of two molecular species, IL-1α and IL-1β. Anakinra (Kineret), a recombinant human IL-1 receptor antagonist, is regarded as a biological agent which blocks the inflammatory effects of IL-1. The aim of this review was to search the literatures and summarizes in vivo, in vitro and human studies on anakinra uses in dermatological disorders. The results show that anakinra is currently used clinically for the treatment of a variety of skin conditions such as psoriasis, atopic dermatitis, photoagaing, melanoma, Schnitzler syndrome, pyoderma gangraenosum, PAPA syndrome, hidradenitis suppurativa, lamellar ichthyosis, Sweet's syndrome, panniculitis, Muckle-Wells syndrome, familial Mediterranean fever, SAPHO syndrome and other disorders. Notably, anakinra is expensive to produce and administer. Injection is the route of therapy and allergic reaction is most possible.
白细胞介素（IL）-1是一种关键的促炎细胞因子，由两种分子类型组成，即IL-1α和IL-1β。阿那白滞素（凯纷）是一种重组人IL-1受体拮抗剂，被视为一种可阻断IL-1炎症作用的生物制剂。本综述的目的是检索文献，并总结阿那白滞素在皮肤病中的体内、体外及人体研究。结果表明，阿那白滞素目前在临床上用于治疗多种皮肤疾病，如银屑病、特应性皮炎、光老化、黑色素瘤、施尼茨勒综合征、坏疽性脓皮病、PAPA综合征、化脓性汗腺炎、板层状鱼鳞病、斯威特综合征、脂膜炎、穆克-韦尔斯综合征、家族性地中海热、滑膜炎、痤疮、脓疱病、骨肥厚、骨炎综合征及其他疾病。值得注意的是，阿那白滞素的生产和给药成本高昂。治疗途径为注射，最可能出现过敏反应。
