Pierard G E
J Cutan Pathol. 1979 Aug;6(4):237-42. doi: 10.1111/j.1600-0560.1979.tb01130.x.
Diffuse alopecia related to ingestion of toxic metals from the environment has been observed in 36 patients. Copper, arsenic, mercury and cadmium were involved and the intensity of disturbance of the hair cycle, heralded by presence of dystrophic hairs, was proportional to the amount of toxic material detected in blood and urine. Toxicity can be observed in vitro by measuring labeled cells on squash preparations after incorporation of tritiated uridine and thymidine in plucked hairs. The labeling indexes, as well as the ratio between cells entering the S phase and the viable cells were always lower in toxic alopecia than in normal hair. Toxic metals do not seem to affect the morphology of the hair shaft.
在36名患者中观察到与从环境中摄入有毒金属相关的弥漫性脱发。涉及的有毒金属有铜、砷、汞和镉，毛发周期紊乱的强度（以营养不良性毛发的出现为预兆）与血液和尿液中检测到的有毒物质数量成正比。通过在拔除的毛发中掺入氚标记的尿苷和胸腺嘧啶后，在压片标本上测量标记细胞，可在体外观察到毒性。在中毒性脱发中，标记指数以及进入S期的细胞与活细胞的比例总是低于正常毛发。有毒金属似乎不会影响毛干的形态。
