Abdel Aziz Abeer M, Sh Hamed Sameera, Gaballah Mohammad A
Department of Dermatology, Andrology and Sexually Transmitted Diseases, Faculty of Medicine, Mansoura University, El-Gomhoria St., Mansoura, Egypt.
Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, El-Gomhoria St., Mansoura, Egypt.
Int J Trichology. 2015 Jul-Sep;7(3):100-6. doi: 10.4103/0974-7753.167465.
Hair loss is a common and distressing problem that can affect both males and females of all ages. Chronic telogen effluvium (CTE) is idiopathic diffuse scalp hair shedding of at least 6 months duration. Hair loss can be one of the symptoms of metal toxicity. Lead (Pb) and cadmium (Cd) are highly toxic metals that can cause acute and chronic health problems in human. The aim of the present study is to determine if there is a relationship between these metals and CTE in women and if CTE is also associated with changes in zinc (Zn) or iron (Fe) blood levels.
Pb, Cd, Fe and Zn total blood levels were determined in 40 female patients fulfilling the criteria of CTH and compared with total blood levels of same elements in 30 well-matched healthy women.
Quantitative analysis of total blood Fe, Zn, Pb and Cd revealed that there were no significant differences between patients and controls regarding Fe, Zn, and Pb. Yet, Cd level was significantly higher in patients than controls. In addition, Cd level showed significant positive correlation with the patient's body weight.
Estimation of blood Pb and Cd levels can be important in cases of CTE as Cd toxicity can be the underlying hidden cause of such idiopathic condition.
脱发是一个常见且令人苦恼的问题，可影响所有年龄段的男性和女性。慢性休止期脱发（CTE）是一种特发性弥漫性头皮脱发，持续时间至少6个月。脱发可能是金属中毒的症状之一。铅（Pb）和镉（Cd）是剧毒金属，可导致人类出现急性和慢性健康问题。本研究的目的是确定这些金属与女性CTE之间是否存在关联，以及CTE是否也与血液中锌（Zn）或铁（Fe）水平的变化有关。
测定了40名符合CTH标准的女性患者的血液中Pb、Cd、Fe和Zn的总水平，并与30名匹配良好的健康女性的相同元素的血液总水平进行了比较。
血液中Fe、Zn、Pb和Cd的定量分析显示，患者与对照组在Fe、Zn和Pb方面无显著差异。然而，患者的Cd水平显著高于对照组。此外，Cd水平与患者体重呈显著正相关。
在CTE病例中，血液中Pb和Cd水平的评估可能很重要，因为Cd毒性可能是这种特发性疾病的潜在隐藏原因。
