Usanga E A, Akwiwu J O
Department of Haematology & Blood Transfusion, College of Medical Sciences, University of Calabar, Nigeria.
East Afr Med J. 1990 Jun;67(6):437-41.
The prevalence and titre of anti-A and anti-B haemolysin antibodies was determined in pregnant and non-pregnant women in a Nigerian community. The results show that alpha haemolysin occurs less frequently than beta-haemolysin in both pregnant and non-pregnant subjects. However, the prevalence of alpha haemolysin was significantly higher in pregnant subjects than in the non-pregnant ones. Surprisingly, the prevalence of haemolysin was significantly lower among the pregnant group than the non-pregnant group. These findings seem to suggest that the foetus probably plays a dual role in alpha and beta-haemolysin production--it enhances the production of alpha-haemolysin while suppressing that of beta-haemolysin. These findings offer explanations for the usually observed low frequency of occurrence of haemolytic disease of the newborn due to ABO incompatibility.
在尼日利亚一个社区的孕妇和非孕妇中测定了抗A和抗B溶血素抗体的患病率和滴度。结果显示，在孕妇和非孕妇中，α溶血素出现的频率低于β溶血素。然而，孕妇中α溶血素的患病率显著高于非孕妇。令人惊讶的是，孕妇组中溶血素的患病率显著低于非孕妇组。这些发现似乎表明，胎儿可能在α和β溶血素的产生中起双重作用——它增强α溶血素的产生，同时抑制β溶血素的产生。这些发现为通常观察到的由于ABO血型不相容导致的新生儿溶血病发生率较低提供了解释。
