Emeribe A O
Department of Haematology, College of Medical Sciences, University of Calabar, Nigeria.
East Afr Med J. 1990 Mar;67(3):205-8.
Six hundred and two blood donors were screened for alpha (alpha) and beta (beta) haemolysins using standard tube technique at 37 degrees C for 1 hour. The prevalence of beta haemolysin in group A donors was 12.1% while that of alpha haemolysin in group B donors was 5%. 21.4% of the donors had alpha, beta and alpha + beta haemolysins in their sera. The frequency of group O donors with alpha only in their sera was 5.7% which is comparable to that in B donors. beta haemolysin occurring alone in group O subjects was 8.6% which is not statistically significant from the 12.1% prevalence in A donors (P greater than 0.05). Total haemolysin frequency in O donors was 30.6% which is significantly higher than the 21.4% prevalence of the entire donors (P less than 0.005). Summation of occurrence of beta haemolysins appearing singly in group O donors (14.3%) is comparable to the prevalence of alpha + beta appearing concurrently (16.3%). Rhesus D distribution had no significant influence on prevalence of alpha and beta haemolysins. There was no significant difference between the different age groups of the donors. It is concluded that the use of O blood for A or B recipients be discontinued considering the high frequency rate of 30.6% for alpha and beta haemolysins in group O donors.
采用标准试管技术，在37摄氏度下对602名献血者进行1小时的α（α）和β（β）溶血素筛查。A组献血者中β溶血素的流行率为12.1%，而B组献血者中α溶血素的流行率为5%。21.4%的献血者血清中含有α、β和α + β溶血素。仅血清中含有α的O组献血者频率为5.7%，与B组献血者相当。O组受试者中单独出现β溶血素的比例为8.6%，与A组献血者12.1%的流行率相比无统计学意义（P大于0.05）。O组献血者中总溶血素频率为30.6%，显著高于所有献血者21.4%的流行率（P小于0.005）。O组献血者中单独出现β溶血素的发生率（14.3%）与同时出现α + β的流行率（16.3%）之和相当。恒河猴D分布对α和β溶血素的流行率没有显著影响。不同年龄组的献血者之间没有显著差异。结论是，考虑到O组献血者中α和β溶血素的高频率率为30.6%，应停止将O型血用于A或B型受血者。
