The Psychiatric Laboratory and The Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China.
Gen Hosp Psychiatry. 2012 Sep-Oct;34(5):571-7. doi: 10.1016/j.genhosppsych.2012.05.015. Epub 2012 Jul 12.
Despite the high prevalence of depression and its considerable impact on the population, knowledge about the pathogenesis of the illness and the antidepressant treatment response is still unknown.
A total of 397 patients with major depression disorder (MDD) and 473 normal controls were employed in the present research. Twelve single nucleotide polymorphisms (SNPs) within the adenomatous polyposis coli (APC) and receptor accessory protein (REEP5) genes were selected for genotyping using the GoldenGate genotyping assay. A total of 165 MDD patients completed a 6-week antidepressant treatment. Responders were defined as patients with at least a 50% reduction in Hamilton Rating Scale for Depression total scores posttreatment.
Two SNPs (rs2464805 and rs563556) within the APC gene exhibited a statistically significant association with MDD when analyzed by genotype and allele frequencies. Three SNPs (rs495794, rs153549 and rs153560) in the REEP5 gene showed significant statistical differences between the responders and nonresponders.
The APC gene may be one of the susceptibility genes for MDD as well as a genetic link between psychiatric disease and cancer. REEP5 gene polymorphisms may influence antidepressant treatment response in MDD.
尽管抑郁症的患病率很高，对人群的影响也很大，但对其发病机制和抗抑郁治疗反应的了解仍不清楚。
本研究共纳入 397 例重度抑郁症（MDD）患者和 473 例正常对照者。采用 GoldenGate 基因分型检测技术，对 APC 和 REEP5 基因内的 12 个单核苷酸多态性（SNP）进行基因分型。共 165 例 MDD 患者完成了 6 周的抗抑郁治疗。以汉密尔顿抑郁量表（HAMD）总分减分率≥50%为有效标准定义为有效者。
在分析基因型和等位基因频率时，APC 基因内的两个 SNP（rs2464805 和 rs563556）与 MDD 有显著的统计学关联。REEP5 基因中的三个 SNP（rs495794、rs153549 和 rs153560）在应答者和无应答者之间有显著的统计学差异。
APC 基因可能是 MDD 的易感基因之一，也是精神疾病与癌症之间的遗传联系。REEP5 基因多态性可能影响 MDD 的抗抑郁治疗反应。
