Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, China; Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China.
Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, China; Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China; Department of Mental Health, Shanxi Medical University, Taiyuan, China.
Neurosci Lett. 2020 Sep 25;736:135292. doi: 10.1016/j.neulet.2020.135292. Epub 2020 Aug 5.
At present, the etiology and pathogenesis of major depressive disorder(MDD) are still unclear. Some studies have shown that toll-like receptor 4 may play an important role in MDD. However, little is currently known about the association between TLR4 single gene polymorphisms (SNPs) and depressive symptoms and antidepressant efficacy.The aim of this study is to analyze whether TLR4 SNPs are associated with depressive symptoms and antidepressant efficacy. The study consisted of 438 patients with first-episode depression. We analyzed three TLR4 SNPs (rs1927911, rs11536889, and rs7873784) and obtained the baseline and 6-week scores using the 17-item Hamilton Depression Rating Scale (HAMD17) and its five-factor model. Allelic and genotypic association tests between TLR4 SNPs and HAMD17 total and cluster scores were performed with UNPHASED, while chi-square tests to analyze the association between TLR4 SNPs and response to antidepressants were performed with SPSS. Patients with the rs1927911-GG genotype exhibited higher scores of anxiety (physical symptoms) and anxiety (somatic). Patients with rs1927911-G also exhibited higher anxiety (physical symptoms) and anxiety (somatic) scores. Patients with rs11536889-GG had significantly lower suicide scores and higher psychomotor retardation scores. Patients with rs11536889-G also had significantly lower suicide scores and higher psychomotor retardation scores. Patients with rs7873784-G had higher anxiety (physical symptoms) and anxiety (psychological) scores. There was no significant difference between antidepressant efficacy and TLR4 gene polymorphisms. These findings provide evidence that TLR4 plays an important role in anxiety, suicide, and other symptoms in patients with MDD. No relationship was found between TLR4 gene polymorphisms and antidepressant efficacy in this study. Further research is needed on gene polymorphisms and the expression of TLR4 in patients with MDD.
目前，重度抑郁症（MDD）的病因和发病机制仍不清楚。一些研究表明，Toll 样受体 4 可能在 MDD 中起重要作用。然而，目前对于 TLR4 单核苷酸多态性（SNPs）与抑郁症状和抗抑郁疗效之间的关系知之甚少。本研究旨在分析 TLR4 SNPs 是否与抑郁症状和抗抑郁疗效有关。该研究包括 438 例首发抑郁症患者。我们分析了三个 TLR4 SNPs（rs1927911、rs11536889 和 rs7873784），并使用 17 项汉密尔顿抑郁评定量表（HAMD17）及其五因子模型获得基线和 6 周评分。使用 UNPHASED 进行 TLR4 SNPs 与 HAMD17 总分和聚类评分之间的等位基因和基因型关联检验，使用 SPSS 进行 TLR4 SNPs 与抗抑郁药反应之间的关联的卡方检验。rs1927911-GG 基因型患者的焦虑（躯体症状）和焦虑（躯体）评分较高。rs1927911-G 基因型患者的焦虑（躯体症状）和焦虑（躯体）评分也较高。rs11536889-GG 基因型患者的自杀评分较低，精神运动迟滞评分较高。rs11536889-G 基因型患者的自杀评分也较低，精神运动迟滞评分较高。rs7873784-G 基因型患者的焦虑（躯体症状）和焦虑（心理）评分较高。抗抑郁疗效与 TLR4 基因多态性之间无显著差异。这些发现为 TLR4 在 MDD 患者的焦虑、自杀和其他症状中发挥重要作用提供了证据。本研究未发现 TLR4 基因多态性与抗抑郁疗效之间存在相关性。需要进一步研究 MDD 患者 TLR4 基因多态性与 TLR4 表达的关系。
