新型 C-核苷 2-脱氧苯甲酰胺核苷的合成途径。
Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside.
机构信息
Queen's University Belfast, John King Laboratory, School of Pharmacy, Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK.
出版信息
Bioorg Med Chem Lett. 2012 Aug 15;22(16):5204-7. doi: 10.1016/j.bmcl.2012.06.069. Epub 2012 Jun 28.
Abstract
2-Deoxy-C-nucleosides are a subcategory of C-nucleosides that has not been explored extensively, largely because the synthesis is less facile. Flexible synthetic procedures giving access to 2-deoxy-C-nucleosides are therefore of interest. To exemplify the versatility and highlight the limitations of a synthetic route recently developed to that effect, the first synthesis of 2-deoxy benzamide riboside is reported. Biological properties of this novel C-nucleoside are also discussed.
摘要
2-脱氧-C-核苷是 C-核苷的一个亚类，尚未得到广泛研究，主要是因为其合成较为困难。因此，能够获得 2-脱氧-C-核苷的灵活合成方法具有重要意义。为了举例说明最近开发的一种合成方法的多功能性和局限性，我们首次报道了 2-脱氧苯甲酰胺核苷的合成。还讨论了该新型 C-核苷的生物学性质。
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