古巴的卡波西肉瘤和人类疱疹病毒 8：B 亚型扩张的证据。

Kaposi's Sarcoma and Human Herpesvirus 8 in Cuba: evidence of subtype B expansion.

机构信息

Virology Department, Institute of Tropical Medicine Pedro Kouri, Havana City, Cuba.

出版信息

Virology. 2012 Oct 25;432(2):361-9. doi: 10.1016/j.virol.2012.06.014. Epub 2012 Jul 12.

DOI:10.1016/j.virol.2012.06.014

PMID:22795824

Abstract

OBJECTIVE

To evaluate the temporal distribution (1991-2009) and associated variation of KSHV subtypes in Cuba.

METHOD

Phylogenetic characterization based on the KSHV K1 gene was performed using 90 KSHV positive samples.

RESULTS

Molecular characterization confirmed the prevalence of a wide range of KSHV subtypes (A: n=48 [A5=12]; C: n=15; B: n=22; and E: n=5). In the current study, we observed a significant increase in HHV-8 subtype B after 2004 (p=0.0063). This Subtype B in Cuba was associated with: heterosexual behaviour (OR: 3.63, CI: 1,2-10,98; p=0.03), with the antecedent of acquiring HIV/KSHV in Africa (p=0.0003), with nodular stage of KS lesions (OR 4.2, CI: 1.1 to 15.7; p=0.04).

CONCLUSION

Our study is the first to report KSHV Subtype B expansion in Cuba, that might be reflective of a change in human behavioural pattern.

摘要

目的

评估 1991 年至 2009 年期间古巴卡波西肉瘤相关疱疹病毒（KSHV）亚型的时间分布及相关变异情况。

方法

对 90 份 KSHV 阳性样本进行 KSHV K1 基因的系统发育特征分析。

结果

分子特征分析证实了 KSHV 多种亚型的广泛流行（A 型：n=48 [A5=12]；C 型：n=15；B 型：n=22；E 型：n=5）。本研究中，我们观察到 2004 年后 B 型 HHV-8 显著增加（p=0.0063）。在古巴，B 型与异性性行为（OR：3.63，CI：1.2-10.98；p=0.03）、非洲获得 HIV/KSHV 的既往史（p=0.0003）和 KS 病变结节期相关（OR 4.2，CI：1.1-15.7；p=0.04）。