Enhancement of haemopoietic recovery in sublethally gamma-irradiated mice by the joint use of indomethacin and cystamine.

The effects of indomethacin and cystamine, administered prior to gamma-irradiation of mice, were investigated. Synergistic enhancement of haemopoietic recovery was observed under the conditions of a joint use of both drugs. The reason for this synergistic action is probably a joint operation of two mechanisms, i.e., the lowering of the radiosensitivity of haemopoietic stem cells by cystamine and the increase of the proliferation of surviving haemopoietic cells by indomethacin.