Department of Studies in Chemistry, Mangalore University, Mangalagangotri 574 199, India.
Eur J Med Chem. 2012 Aug;54:597-604. doi: 10.1016/j.ejmech.2012.06.011. Epub 2012 Jun 15.
A novel series of 1-substituted aminomethyl-3-[1-(4-isobutylphenyl)ethyl]-4-(3-aryl-4-sydnonylidene) amino-1,2,4-triazol-5-thiones (9), was prepared from the 3-[1-(4-isobutylphenyl)ethyl]-4-(3-aryl-4-sydnonylidene) amino 5-mercapto-1,2,4-triazoles (8) by aminomethylation with formaldehyde and secondary amine. The structures of Schiff bases (8) and Mannich bases (9) were characterized on the basis of IR, NMR, mass spectra1 data and elemental analysis. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activities. Mannich bases (9) carrying piperidine and morpholine residues showed promising anti-inflammatory and analgesic activity.
新型系列 1-取代氨甲基-3-[1-(4-异丁基苯基)乙基]-4-(3-芳基-4- sydnonylidene)氨基-1,2,4-三唑-5-硫酮（9），是由 3-[1-(4-异丁基苯基)乙基]-4-(3-芳基-4- sydnonylidene)氨基 5-巯基-1,2,4-三唑（8）与甲醛和仲胺进行氨甲基化反应制备的。席夫碱（8）和曼尼希碱（9）的结构是基于红外光谱、核磁共振、质谱 1 数据和元素分析来表征的。新合成的化合物进行了抗炎和镇痛活性筛选。带有哌啶和吗啉残基的曼尼希碱（9）显示出有希望的抗炎和镇痛活性。
