Division of Science and Technology, Department of Chemistry, University of Education, Lahore, Pakistan.
Department of Chemistry, University of Lahore, Lahore, Pakistan.
PLoS One. 2020 Jun 4;15(6):e0229891. doi: 10.1371/journal.pone.0229891. eCollection 2020.
A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino- and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3-5 minutes of exposure to ultra-sound. The synthesized compounds were characterized by means of IR, 1HNMR and Mass spectrometry. The synthesized compounds were also screened for their antibacterial potential against Gram-negative (Escherichia coli, Shigella sonnei, Pseudomonas aeruginosa and Salmonella typhi) and two Gram-positive (Staphylococcus aureus and Bacillus subtilis) strains.
一种简便的方法已经被开发出来，用于合成取代和未取代的 3-氨基-和 4-氨基-1,2,4-三唑衍生的席夫碱。将氨基三唑与各种芳香醛缩合，在超声暴露 3-5 分钟内即可得到所需的席夫碱，产率很高。通过红外光谱、1HNMR 和质谱对合成的化合物进行了表征。还对这些化合物的抗菌潜力进行了筛选，包括革兰氏阴性菌（大肠杆菌、痢疾志贺菌、铜绿假单胞菌和伤寒沙门氏菌）和两种革兰氏阳性菌（金黄色葡萄球菌和枯草芽孢杆菌）。
