Keble College, Oxford, OX1 3PG, UK.
Trends Mol Med. 2012 Dec;18(12):691-4. doi: 10.1016/j.molmed.2012.06.004. Epub 2012 Jul 14.
The global distribution of HIV-1 subtypes and recombinants is extremely complex and dynamic. The increasing diversity has profound implications for many aspects of the pandemic, including viral pathogenicity, transmission, diagnosis, treatment, and vaccine development. HIV-1 genetic diversity surveillance is crucial in tackling the pandemic, but systematic surveillance at national, regional, and global levels has, to date, been lacking. Here, we discuss methods for gathering representative HIV-1 molecular epidemiology data and incorporating these into a comprehensive global HIV-1 diversity monitoring system.
HIV-1 亚型和重组体在全球的分布极其复杂和动态。这种多样性的增加对大流行的许多方面都有深远的影响，包括病毒的致病性、传播、诊断、治疗和疫苗开发。HIV-1 遗传多样性监测对于应对大流行至关重要，但迄今为止，国家、区域和全球各级都缺乏系统的监测。在这里，我们讨论了收集有代表性的 HIV-1 分子流行病学数据的方法，并将这些数据纳入一个全面的全球 HIV-1 多样性监测系统。
